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Fig. 1 | Trials

Fig. 1

From: Simulating therapeutic drug monitoring results for dose individualisation to maintain investigator blinding in a randomised controlled trial

Fig. 1

Observed plasma lithium concentrations in individuals randomised to treatment arm (orange circles) and sham lithium concentrations simulated for individuals randomised to placebo arm (blue triangles) by date of sample. Solid horizontal lines represent therapeutic range; dashed horizontal line represents adjusted lower threshold. Distribution of simulated and measured lithium concentration density estimates provided as marginal plot (dashed = placebo; solid = lithium)

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Trials

ISSN: 1745-6215