Table 1 Inclusion and exclusion criteria

Inclusion criteria:

 Adult (≥18 years) affected by trauma and

 Judged to have significant haemorrhage or

 Predicted to require significant transfusion with ABC Score ≥2

 or by treating clinician judgment

Exclusion criteria:

 Injury judged incompatible with survival

 Previous fibrinogen administration this admission

 Pretrauma centre dedicated fibrinogen replacement

 Known objection to blood products

 Known coagulation disorder

 Pregnancy

 Enrolment in competing study