Primary outcome | Cumulative fluid balance 5 days after randomisation |
Secondary outcomes | Mean daily fluid balance during ICU stay |
Cumulative fluid balance during the entire ICU stay | |
Time to neutral cumulative fluid balance | |
Number of patients with one or more major protocol violations | |
Accumulated SARs in each intervention arm during the ICU stay | |
Exploratory outcomes | All-cause mortality at day 90 |
Days alive and out of hospital within 90 days of follow-up | |
Days alive without mechanical ventilation within 90 days of follow-up | |
Days alive without vasopressor/inotropic therapy within 90 days follow-up | |
Days alive without RRT within 90 days follow-up | |
Renal recovery at day 90 |