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Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

  • T. Bluth1,
  • R. Teichmann1,
  • T. Kiss1,
  • I. Bobek2,
  • J. Canet3,
  • G. Cinnella4,
  • L. De Baerdemaeker5,
  • C. Gregoretti6,
  • G. Hedenstierna7,
  • S. N. Hemmes8, 9,
  • M. Hiesmayr10, 11, 12, 13,
  • M. W. Hollmann8, 9,
  • S. Jaber14,
  • J. G. Laffey15, 16, 17, 18,
  • M. J. Licker19,
  • K. Markstaller20,
  • I. Matot21,
  • G. Müller22,
  • G. H. Mills23,
  • J. P. Mulier24,
  • C. Putensen25,
  • R. Rossaint26,
  • J. Schmitt22,
  • M. Senturk27,
  • A. Serpa Neto28, 29,
  • P. Severgnini30,
  • J. Sprung31,
  • M. F. Vidal Melo32,
  • H. Wrigge33,
  • M. J. Schultz9, 34,
  • P. Pelosi35,
  • M. Gama de Abreu1Email authorView ORCID ID profile,
  • for the PROBESE investigators,
  • and the PROtective VEntilation Network (PROVEnet) and
  • on behalf of the Clinical Trial Network of the European Society of Anaesthesiology (ESA)
Trials201718:202

https://doi.org/10.1186/s13063-017-1929-0

Received: 4 October 2016

Accepted: 29 March 2017

Published: 28 April 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
4 Oct 2016 Submitted Original manuscript
23 Mar 2017 Reviewed Reviewer Report - Gui-zhi Du
24 Mar 2017 Reviewed Reviewer Report - Elena Bignami
Resubmission - Version 2
Submitted Manuscript version 2
Publishing
29 Mar 2017 Editorially accepted
28 Apr 2017 Article published 10.1186/s13063-017-1929-0

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus
(2)
Aneszteziológiai és Intenzív Terápiás Klinika, Semmelweis Egyetem
(3)
Department of Anesthesiology, Hospital Universitari Germans Trias i Pujol
(4)
Department of Anesthesiology and Intensive Care Medicine, University of Foggia
(5)
Department of Anesthesiology, Ghent University Hospital
(6)
Department of Biopathology and Medical Biotechnologies, Policlinico “P. Giaccone”
(7)
Section of Clinical Physiology, Department of Medical Sciences, University Hospital
(8)
Department of Anesthesiology, Academic Medical Center, University of Amsterdam
(9)
Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam
(10)
Division of Cardiac Surgery, Medical University of Vienna
(11)
Division of Thoracic Surgery, Medical University of Vienna
(12)
Division of Vascular Surgery, Medical University of Vienna
(13)
Department of Anesthesia, Intensive Care and Pain Medicine, Medical University of Vienna
(14)
Department of Critical Care Medicine and Anesthesiology (SAR B), Saint Eloi University Hospital
(15)
Critical Care Medicine Program, Department of Anesthesia, Saint Michael’s Hospital
(16)
Department of Anesthesia, University of Toronto
(17)
Department of Physiology, University of Toronto
(18)
Interdepartmental Division of Critical Care Medicine, University of Toronto
(19)
Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital Geneva
(20)
Department of Anesthesia, Intensive Care and Pain Medicine, Medical University of Vienna
(21)
Department of Anesthesiology and Critical Care, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University
(22)
Center for Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, Technical University Dresden
(23)
Operating Services, Critical Care and Anaesthesia (OSCCA), Sheffield Teaching Hospitals and University of Sheffield
(24)
Department of Anesthesiology, AZ Sint Jan Brugge-Oostende AV
(25)
Department of Anesthesiology and Intensive Care Medicine, University of Bonn
(26)
Department of Anesthesiology, University of Aachen
(27)
Department of Anesthesiology and Intensive Care Medicine, Istanbul Medical Faculty, University of Istanbul
(28)
Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Faculdade de Medicina do ABC
(29)
Program of Post-Graduation, Research and Innovation, Faculdade de Medicina do ABC
(30)
Department of Biotechnology and Sciences of Life, University of Insubria, ASST dei Sette Laghi, Ospedale di Cricolo e Fondazione Macchi
(31)
Department of Anesthesiology, Mayo Clinic
(32)
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School
(33)
Department of Anesthesiology and Intensive Care Medicine, University of Leipzig
(34)
Department of Intensive Care, Academic Medical Center, University of Amsterdam
(35)
Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino – IST, University of Genoa

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