Maintenance tegafur-uracil versus observation following an adjuvant oxaliplatin-based regimen in patients with stage III colon cancer after radical resection: study protocol for a randomized controlled trial

Table 1 Data on the investigational product

Name of active ingredients	Tegafur	Uracil
Description	Tegafur occurs as a white crystalline powder. It is soluble in methanol, sparingly in water and ethanol, and slightly in ether. It is soluble in dilute sodium hydroxide.	Uracil occurs as a white crystal or crystalline powder, free of odor or taste. It is slightly soluble in water; slightly soluble in methanol, ethanol and acetone; and insoluble in ethyl acetate and chloroform.
Structure
Chemical name	1-(2-tetrahydrofuryl)-5-fluorouracid 5-fluoro-1-(2-tetrahydrofuryl)-2,4 (1H,3H)-pyrimidinedione (IUPAC)	2,4(1H,3H)-pyrimidinedione
Molecular formula	C₈H₉FN₂O₃	C₄H₄N₂O₂
Molecular weight	200.17	112.09
Melting point	166 °C–171 °C	Approximately 335 °C
Contents	Each capsule contains 100 mg tegafur and 224 mg uracil.
Storage condition	Below 30 °C

ISSN: 1745-6215