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Table 1 Assumptions used for sample size calculation for the first 14 weeks of life

From: Early versus late BCG vaccination in HIV-1-exposed infants in Uganda: study protocol for a randomized controlled trial

Assumption Estimated level
Two-sided significance level 0.05
Ratio of sample size early/late BCG vaccination 1
Percent of vaccinated at 14 weeks of age with severe illness 15
Percent of vaccinated at birth with severe illness 10
Risk ratio: 0.7
Risk difference 5
Total sample size (i.e., in both trial arms) 1914
  1. BCG Bacillus Calmette-Guérin