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Table 4 Multivariate metaregression examining factors associated with effect size

From: The association of funding source on effect size in randomized controlled trials: 2013–2015 – a cross-sectional survey and meta-analysis

Factor

Exponentiated coefficient, OR (95% CI)

p Value

Medical journal

The Lancet

Reference

 

JAMA

−0.21 (−0.17, 0.12)

0.77

New England Journal of Medicine

0.024 (−0.10, 0.15)

0.70

Sample size

 Mean

0 (0, 0)

0.76

Intervention type

 Drug

Reference

 

 Device

−0.21 (−0.40, −0.01)

0.04

 Procedure

0.04 (−0.15, 0.23)

0.67

 Procedure and/or device/drug

−0.20 (−0.40, −0.00)

0.049

 Behavior

0.02 (−0.19, 0.23)

0.85

 Other

−0.18 (−0.35, 0.00)

0.053

Endpoint

 Clinical

Reference

 

 Surrogate

0.38 (0.25, 0.51)

<0.001

Funding source

 Profit

Reference

 

 Mixed

−0.22 (−0.37, 0.07)

0.005

 Nonprofit

−0.28 (−0.42, −0.15)

<0.001