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Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial

  • Matthew W. Semler1Email author,
  • Wesley H. Self2,
  • Li Wang3,
  • Daniel W. Byrne3,
  • Jonathan P. Wanderer4, 5,
  • Jesse M. Ehrenfeld4, 5, 6, 7,
  • Joanna L. Stollings8,
  • Avinash B. Kumar4,
  • Antonio Hernandez4,
  • Oscar D. Guillamondegui6,
  • Addison K. May6,
  • Edward D. Siew9,
  • Andrew D. Shaw4,
  • Gordon R. Bernard1,
  • Todd W. Rice1,
  • for the Isotonic Solutions and Major Adverse Renal Events Trial (SMART) Investigators and
  • the Pragmatic Critical Care Research Group
Trials201718:129

https://doi.org/10.1186/s13063-017-1871-1

Received: 12 December 2016

Accepted: 1 March 2017

Published: 16 March 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting info@biomedcentral.com.

Original Submission
12 Dec 2016 Submitted Original manuscript
27 Feb 2017 Reviewed Reviewer Report - Isabelle Boutron
28 Feb 2017 Author responded Author comments - Matthew Semler
Resubmission - Version 2
28 Feb 2017 Submitted Manuscript version 2
Publishing
1 Mar 2017 Editorially accepted
16 Mar 2017 Article published 10.1186/s13063-017-1871-1

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting info@biomedcentral.com. All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center
(2)
Department of Emergency Medicine, Vanderbilt University Medical Center
(3)
Department of Biostatistics, Vanderbilt University Medical Center
(4)
Department of Anesthesiology, Vanderbilt University Medical Center
(5)
Department of Biomedical Informatics, Vanderbilt University Medical Center
(6)
Department of Surgery, Vanderbilt University Medical Center
(7)
Department of Health Policy, Vanderbilt University Medical Center
(8)
Department of Pharmaceutical Services, Vanderbilt University Medical Center
(9)
Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease (VCKD) and Vanderbilt Integrated Program for AKI Research (VIP-AKI), Vanderbilt University Medical Center

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