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This article has Open Peer Review reports available.

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Why clinical trial outcomes fail to translate into benefits for patients


Received: 13 October 2016

Accepted: 28 February 2017

Published: 14 March 2017

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
13 Oct 2016 Submitted Original manuscript
14 Nov 2016 Reviewed Reviewer Report - Malcolm Macleod
17 Nov 2016 Reviewed Reviewer Report - Paula Williamson
24 Feb 2017 Author responded Author comments - Carl Heneghan
Resubmission - Version 2
24 Feb 2017 Submitted Manuscript version 2
28 Feb 2017 Editorially accepted
14 Mar 2017 Article published 10.1186/s13063-017-1870-2

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Science, University of Oxford, Radcliffe Observatory Quarter, Oxford, UK