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A prospective, randomised, placebo-controlled, double-masked, three-armed, multicentre phase II/III trial for the Study of a Topical Treatment of Ischaemic Central Retinal Vein Occlusion to Prevent Neovascular Glaucoma – the STRONG study: study protocol for a randomised controlled trial

  • Katrin Lorenz1Email authorView ORCID ID profile,
  • Yvonne Scheller1,
  • Katharina Bell1,
  • Franz Grus1,
  • Katharina A. Ponto1, 2,
  • Felix Bock3,
  • Claus Cursiefen3,
  • Jens Flach4,
  • Marta Gehring5,
  • Tunde Peto6,
  • Rufino Silva7, 8, 9,
  • Yossi Tal10 and
  • Norbert Pfeiffer1

Received: 27 October 2016

Accepted: 20 February 2017

Published: 16 March 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
27 Oct 2016 Submitted Original manuscript
28 Oct 2016 Author responded Author comments - Katrin Lorenz
Resubmission - Version 2
28 Oct 2016 Submitted Manuscript version 2
20 Feb 2017 Reviewed Reviewer Report - Marion Munk
Resubmission - Version 3
Submitted Manuscript version 3
20 Feb 2017 Editorially accepted
16 Mar 2017 Article published 10.1186/s13063-017-1861-3

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

Department of Ophthalmology, University Medical Center, Johannes Gutenberg-University Mainz
Center for Thrombosis and Hemostasis, University Medical Center, Johannes Gutenberg-University Mainz
Department of Ophthalmology, University of Cologne
Bundesverband Glaukom-Selbsthilfe e.V.
Gene Signal International SA, EPFL Innovation Park-A
NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
Faculty of Medicine, University of Coimbra (FMUC)
Department of Ophthalmology, Coimbra Hospital and University Center (CHUC)
Association for Innovation and Biomedical Research on Light and Image (AIBILI)
TechnoSTAT Ltd.