Table 2 Univariate and multivariable linear regression results. Multivariable estimates are adjusted for all other predictors
Predictor | Unadjusted change in WMH volume at 1 year per unit change in predictor (95% CI) | Unadjusted p value | Adjusted change in WMH volume at 1 year per unit change in predictor (95% CI) | Adjusted p value |
|---|---|---|---|---|
Baseline WMH volume, ml | 0.88 (0.84 to 0.93) | <0.0001 | 0.73 (0.65 to 0.80) | <0.0001 |
Age | 0.91 (0.64 to 1.17) | <0.0001 | −0.02 (−0.14 to 0.10) | 0.75 |
MAP | −0.11 (−0.33 to 0.11) | 0.31 | −0.10 (−0.19 to −0.02) | 0.013 |
PP | 0.19 (0.035 to 0.35) | 0.017 | 0.03 (−0.03 to 0.10) | 0.34 |
Hypertension | 4.89 (−2.77 to 12.54) | 0.21 | −1.40 (−4.06 to 1.26) | 0.30 |
Fazekas score | 11.54 (10.43 to 12.65) | <0.0001 | 2.93 (1.76 to 4.10) | <0.0001 |
Stroke subtype | 0.88 (−5.83 to 7.58) | 0.80 | −0.85 (−3.05 to 1.34) | 0.44 |
Smoking status | −2.30 (−9.16 to 4.56) | 0.51 | 0.17 (−2.24 to 2.57) | 0.89 |
Diabetes | 10.36 (−0.19 to 20.90) | 0.054 | −1.98 (−5.51 to 1.54) | 0.27 |
Hyperlipidaemia | −0.51 (−7.36 to 6.34) | 0.88 | −1.10 (−3.40 to 1.19) | 0.34 |