Sample size determination for a binary response in a superiority clinical trial using a hybrid classical and Bayesian procedure

Table 1 Analysis of traditional design performance

Uncertainty	m ₂−m ₁	Performance
\(\tau _{1}^{2}=\tau _{2}^{2}\)	<1/3	Increases as \(\tau _{1}^{2}=\tau _{2}^{2}\) increases
	>1/3	Decreases as \(\tau _{1}^{2}=\tau _{2}^{2}\) increases
\(\tau _{1}^{2}\) small	<(1−m ₁)/2	Increases as \(\tau _{2}^{2}\) increases
	>(1−m ₁)/2	Decreases as \(\tau _{2}^{2}\) increases
\(\tau _{1}^{2}\) large	>2/3−m ₁	Increases as \(\tau _{2}^{2}\) increases
	<2/3−m ₁	Decreases as \(\tau _{2}^{2}\) increases

ISSN: 1745-6215