Skip to main content

Table 5 Speed of healing over 6 weeks using unblinded measurements only, with increased difference between measurements

From: Investigating the effect of independent, blinded digital image assessment on the STOP GAP trial

Observed measurement differencea increase

Treatment group

Number in group

Mean (SD) speed of healing (cm2/day)

Difference in means (ciclosporin –prednisolone)

Adjusted differenceb (95% CI)

p value

p valuec

Both treatment groups

 2×

Ciclosporin

57

−0.21 (1.05)

0.004

0.017 (−0.29 to 0.32)

0.91

0.93

Prednisolone

51

−0.21 (0.59)

 5×

Ciclosporin

57

−-0.20 (1.44)

0.122

0.115 (−0.38 to 0.61)

0.65

0.66

Prednisolone

51

−0.33 (1.11)

In ciclosporin group only

 2×

Ciclosporin

57

−0.21 (1.05)

−0.071

0.115 (−0.12 to 0.35)

0.34

0.35

Prednisolone

51

−0.14 (0.42)

 5×

Ciclosporin

57

−0.20 (1.44)

−0.066

0.212 (−0.17 to 0.59)

0.27

0.28

Prednisolone

51

−0.14 (0.42)

  1. aThe differences between measurement methods were calculated by unblinded physical measurement – trial measurement
  2. bAdjusted by stratification factors baseline lesion size and presence of underlying systemic disease
  3. c p value for test of homogeneity between the treatment estimate and the treatment estimate from the STOP GAP trial analysis using trial measurements (see Table 4)