Table 4 Management guideline for trial intervention arm

Obstructive disease: stenosis ≥70%

Positive or negative

1. ACS and secondary preventative therapies

2. Invasive coronary angiography (ICA) ± revascularisation

Moderate non-obstructive disease: stenosis 50–69%

Positive

1. ACS and secondary preventative therapies

2. Consider ICA if uncertainty about the presence of obstructive coronary artery disease or functional testing

Moderate non-obstructive disease: stenosis 50–69%

Negative

1. Secondary preventative therapies

2. Consider ICA if uncertainty about the presence of obstructive coronary artery disease or functional testing

Mild non-obstructive disease: stenosis <50%

Positive

1. Consider ACS and secondary preventative therapies

2. Consider alternative cause of chest pain and troponin rise

Mild non-obstructive disease: stenosis <50%

Negative

1. Discharge with no further follow-up

2. Consider secondary preventative therapies

Normal (no evidence of CAD)

Discharge with no further follow-up