Table 1 Secondary endpoints

1. Clinical, process and patient-centred endpoints

• Hospital length of stay

• Coronary care length of stay

• Proportion of patients receiving invasive coronary angiography (ICA) during index hospitalisation

• Proportion of patients receiving coronary revascularisation during index hospitalisation

• Proportion of patients receiving subsequent unplanned coronary revascularisation after index hospitalisation within 12 months

• Proportion of patients in CTCA arm receiving ICA despite <50% stenosis on CTCA

• Proportion of patients assigned to CTCA with normal or mild non-obstructive disease

• Proportion of patients prescribed ACS therapies during index hospitalisation

• Proportion of patients discharged on prevention treatment or who have alteration in dosage of prevention treatment during index hospitalisation

• Representation or rehospitalisation with suspected ACS/recurrent chest pain within 12 months

• Patient symptoms and quality of life up to 12 months

• Health service resource utilisation

• Patient satisfaction

• Clinician certainty of presenting diagnosis after CTCA

2. Safety

• Proportion of patients with allergy/anaphylaxis/acute kidney injury

• Proportion of patients with alternative diagnoses that relate to clinical presentation identified on CTCA, e.g. aortic dissection or pulmonary embolus

• Proportion of patients with an incidental but potentially concerning finding on CTCA, e.g. malignancy or pulmonary nodules

• Total average radiation exposure from CTCA in the intervention arm during index hospitalisation

3. Health economics

• Incremental cost per quality-adjusted life year (QALY) gained