Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Table 1 Study timeline and trial assessments

Assessments
Screening (telephone)	X
Informed consent (mail)	X
IPAQ questionnaire (mail)	X
3-day food record (mail)	X
Medical questionnaire (mail)	X
		Week 1	Week 6	Week 12
		Baseline (visit1)	Test (visit 2)	Test (visit 3)
Randomisation		X
Intervention allocation		X
Anthropometry measurements		X	X	X
Blood sample		X		X
Food diary		X	X	X
Physical activity		X	X	X
Biochemical analysis		X		X
Fasting plasma glucose		X		X
Fasting plasma insulin		X		X
HbA1c		X		X
Fructosamine		X		X
HOMA IR, HOMA S, HOMA β, QUICKI		X		X
Total cholesterol		X		X
Triglycerides		X		X
HDL-C, LDL-C, Total/HDL-C ratio		X		X
CRP		X		X
Whole blood cell count		X		X
Il-6, Il-1β, adiponectin, leptin		X		X
Capsule count and log record			X	X
Plasma curcumin concentration				X
Erythrocyte fatty acids content		X		X
Adverse event reporting			X	X

IPAQ International Physical Activity Questionnaire, HbA1c glycosylated haemoglobin, HOMA IR Homeostatic Model Assessment for Insulin Resistance, HOMA S Insulin sensitivity, HOMA β beta-cell function, QUICKI Quantitative insulin Sensitivity Check Index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, CRP C-reactive protein, IL-6 interleukin-6, IL-1β interleukin-1 beta

ISSN: 1745-6215