Inclusion criteria | Exclusion criteria |
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- Patients aged between 18 and 70 years - ASA classification 1, 2 or 3 - Body weight > 50 kg - One of the following ambulatory surgical procedures: • Haemorrhoid surgery • Arthroscopy knee • Arthroscopy shoulder • Inguinal hernia repair | - Not meeting inclusion criteria - Cognitive impairment or no understanding of the Dutch language - Preoperative pharmacologic pain treatment and/or a history of chronic pain - Allergy to or a contraindication for taking the study medication (e.g. paracetamol, metamizole, ibuprofen or another non-steroidal anti-inflammatory drug) - Porphyria - Pregnancy or lactation - A history of severe renal, hepatic, pulmonary, or cardiac failure - Current symptoms or a history of gastrointestinal bleeding - Ileus or chronic obstipation - A history of substance abuse, or use of medication with a suppressive effect on the central nervous system - Hypotension - Hematological disease - Use of anti-rheumatic drugs - Rhinosinusitis or nasal polyposis - Glucose-6-phosphate dehydrogenase deficiency - Fever or other signs of infection - For patients undergoing arthroscopy shoulder: refusal of an interscalene block |