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High
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Consistent findings in multiple studies of at least good quality OR one study of excellent quality AND a total sample size of ≥100 patients
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Moderate
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Conflicting findings in multiple studies of at least good quality OR consistent findings in multiple studies of at least fair quality OR one study of good quality AND a total sample size of ≥50 patients
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Low
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Conflicting findings in multiple studies of at least fair quality OR one study of fair quality AND a total sample size of ≥30 patients
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Very low
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Only studies of poor quality OR a total sample size of <30 patients
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Unknown
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No studies
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