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Table 1 Study population: inclusion and exclusion criteria

From: Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial

Inclusion criteria (all criteria must apply):
 • Women with a BRCA1 or BRCA2 germline mutation
 • Age over 18 years
 • Written informed consent
Exclusion criteria:
 • Ongoing chemo- or radiation therapy (recruitment is possible 6 weeks after completing therapy)
 • Metastatic tumor disease
 • Expectancy of life <3 years
 • Limited cardiovascular and lung diseases (unstable CHC, heart failure stage IV, chronic obstructive pulmonary disease GOLD IV, maximal blood pressure at rest >160/100 mmHg)
 • Significant orthopedic problems not allowing exercise
 • Serious diseases not allowing a participation in group interventions (e.g., psychiatric or internal ailment)
 • Karnofsky index <60 %
 • Women with an exercise capacity <50 watts
 • Food allergies not allowing consumption of a Mediterranean dietary pattern
 • Vegans
 • BMI <15 kg/m2
 • Pregnancy
 • Insufficient knowledge of the German language
 • Lack of compliance
 • Current participation in other lifestyle intervention trials
  1. CHC Coronary Heart Condition