Table 1 Study population: inclusion and exclusion criteria

Inclusion criteria (all criteria must apply):

 • Women with a BRCA1 or BRCA2 germline mutation

 • Age over 18 years

 • Written informed consent

Exclusion criteria:

 • Ongoing chemo- or radiation therapy (recruitment is possible 6 weeks after completing therapy)

 • Metastatic tumor disease

 • Expectancy of life <3 years

 • Limited cardiovascular and lung diseases (unstable CHC, heart failure stage IV, chronic obstructive pulmonary disease GOLD IV, maximal blood pressure at rest >160/100 mmHg)

 • Significant orthopedic problems not allowing exercise

 • Serious diseases not allowing a participation in group interventions (e.g., psychiatric or internal ailment)

 • Karnofsky index <60 %

 • Women with an exercise capacity <50 watts

 • Food allergies not allowing consumption of a Mediterranean dietary pattern

 • Vegans

 • BMI <15 kg/m²

 • Pregnancy

 • Insufficient knowledge of the German language

 • Lack of compliance

 • Current participation in other lifestyle intervention trials