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Table 1 Study population: inclusion and exclusion criteria

From: Effects of lifestyle intervention in BRCA1/2 mutation carriers on nutrition, BMI, and physical fitness (LIBRE study): study protocol for a randomized controlled trial

Inclusion criteria (all criteria must apply):  • Women with a BRCA1 or BRCA2 germline mutation  • Age over 18 years  • Written informed consent
Exclusion criteria:  • Ongoing chemo- or radiation therapy (recruitment is possible 6 weeks after completing therapy)  • Metastatic tumor disease  • Expectancy of life <3 years  • Limited cardiovascular and lung diseases (unstable CHC, heart failure stage IV, chronic obstructive pulmonary disease GOLD IV, maximal blood pressure at rest >160/100 mmHg)  • Significant orthopedic problems not allowing exercise  • Serious diseases not allowing a participation in group interventions (e.g., psychiatric or internal ailment)  • Karnofsky index <60 %  • Women with an exercise capacity <50 watts  • Food allergies not allowing consumption of a Mediterranean dietary pattern  • Vegans  • BMI <15 kg/m2  • Pregnancy  • Insufficient knowledge of the German language  • Lack of compliance  • Current participation in other lifestyle intervention trials
  1. CHC Coronary Heart Condition