| Cohort 1 | Cohort 2 | Cohort 3 | |||
---|---|---|---|---|---|---|
S-1226 (4 % CO2) (n = 9) | Placebo (n = 3) | S-1226 (8 % CO2) (n = 9) | Placebo (n = 3) | S-1226 (12 % CO2) (n = 9) | Placebo (n = 3) | |
Age, years | Â | Â | Â | Â | Â | Â |
 Mean ± SD | 35 ± 12 | 35 ± 11 | 35 ± 10 | 31 ± 3 | 33 ± 10 | 27 ± 11 |
 Median | 30 | 36 | 32 | 32 | 30 | 23 |
 Range | 22–55 | 23–45 | 22–51 | 28–34 | 21–45 | 19–39 |
Height, cm | Â | Â | Â | Â | Â | Â |
 Mean ± SD | 170.2 ± 7.1 | 166.7 ± 4.2 | 168.0 ± 10.7 | 171.3 ± 2.8 | 166.4 ± 8.8 | 186.0 ± 6.5 |
 Median | 170.7 | 164.6 | 164.6 | 170.5 | 165.5 | 183.9 |
 Range | 155.7–182.2 | 164.0–171.5 | 155.4–184.5 | 169.0–174.5 | 153.0–181.4 | 180.8–193.2 |
Weight, kg | Â | Â | Â | Â | Â | Â |
 Mean ± SD | 73.5 ± 12.4 | 69.4 ± 13.7 | 69.3 ± 13.2 | 67.4 ± 9.5 | 65.3 ± 9.1 | 81.3 ± 12.7 |
 Median | 75.3 | 63.4 | 65.0 | 62.2 | 62.0 | 75.5 |
 Range | 58.4–96.8 | 59.7–85.1 | 53.1–94.0 | 61.6–78.4 | 51.9–78.0 | 72.6–95.9 |
BMI, kg/m2 | Â | Â | Â | Â | Â | Â |
 Mean ± SD | 25.3 ± 3.6 | 24.8 ± 3.6 | 24.4 ± 2.5 | 22.9 ± 2.4 | 23.6 ± 2.5 | 23.6 ± 4.3 |
 Median | 26.5 | 23.4 | 24.9 | 21.8 | 23.7 | 22.2 |
 Range | 20.0–29.2 | 22.2–28.9 | 19.5–28.5 | 21.2–25.7 | 19.2–26.4 | 20.2–28.4 |
Age group, years, n (%) | Â | Â | Â | Â | Â | Â |
  < 18 | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
 18–40 | 7 (77.8 %) | 2 (66.7 %) | 7 (77.8 %) | 3 (100 %) | 6 (66.7 %) | 3 (100 %) |
 41–55 | 2 (22.2 %) | 1 (33.3 %) | 2 (22.2 %) | 0 (0 %) | 3 (33.3 %) | 0 (0 %) |
Sex, n (%) | Â | Â | Â | Â | Â | Â |
 Female | 2 (22.2 %) | 3 (100 %) | 5 (55.6 %) | 2 (66.7 %) | 8 (88.9 %) | 0 (0 %) |
 Male | 7 (77.8 %) | 0 (0 %) | 4 (44.4 %) | 1 (33.3 %) | 1 (11.1 %) | 3 (100 %) |
Ethnicity, n (%) | Â | Â | Â | Â | Â | Â |
 Hispanic or Latino | 2 (22.2 %) | 1 (33.3 %) | 3 (33.3 %) | 2 (66.7 %) | 4 (44.4 %) | 2 (66.7 %) |
 Not Hispanic or Latino | 7 (77.8 %) | 2 (66.7 %) | 6 (66.7 %) | 1 (33.3 %) | 5 (55.6 %) | 1 (33.3 %) |
Race, n (%) | Â | Â | Â | Â | Â | Â |
 Black | 5 (55.6 %) | 1 (33.3 %) | 4 (44.4 %) | 0 (0 %) | 3 (33.3 %) | 0 (0 %) |
 Other (multiracial white and black) | 0 (0 %) | 1 (33.3 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) | 0 (0 %) |
 White | 4 (44.4 %) | 1 (33.3 %) | 5 (55.6 %) | 3 (100 %) | 6 (66.7 %) | 3 (100 %) |
Heart rate, beats/minute, mean ± SD | 66.2 ± 10.2 | 71.7 ± 7.5 | 61.9 ± 5.4 | 72.7 ± 9.5 | 72.3 ± 12.0 | 70.7 ± 7.4 |
FEV1, L/minute, mean ± SD | 3.4 ± 0.7 | 2.8 ± 0.2 | 3.5 ± 1.0 | 3.9 ± 0.4 | 3.3 ± 0.7 | 4.9 ± 0.9 |
Blood pressure, mmHg,a mean ± SD | 87.3 ± 8.0 | 89.7 ± 5.7 | 85.6 ± 8.0 | 89.2 ± 9.4 | 82.8 ± 9.0 | 87.0 ± 2.4 |