Pain (VAS), cm, mean ± SD
|
2.62 ± 1.37**
|
3.31 ± 1.30**
|
3.64 ± 1.29
|
3.99 ± 1.42
|
2.48 ± 1.30**
|
3.24 ± 1.32*
|
3.62 ± 1.30
|
3.89 ± 1.45
|
Pain changes, cm, mean ± SD
|
−3.06 ± 1.95**
|
−2.37 ± 1.31**
|
−1.85 ± 1.51
|
−1.53 ± 1.70
|
−3.31 ± 1.87**
|
−2.44 ± 1.25*
|
−1.88 ± 1.51
|
−1.63 ± 1.74
|
Tender joint counts, n, mean ± SD
|
3.88 ± 3.73**
|
4.80 ± 3.24
|
4.24 ± 2.54*
|
5.63 ± 4.10
|
3.96 ± 3.89
|
4.80 ± 3.38
|
4.19 ± 2.53
|
5.67 ± 4.32
|
Tender joint changes, n, mean ± SD
|
−5.24 ± 3.54**
|
−3.68 ± 3.19
|
−3.12 ± 2.88
|
−3.61 ± 3.51
|
−5.66 ± 3.46
|
−3.81 ± 3.24
|
−3.21 ± 2.88
|
−3.96 ± 3.54
|
Swollen joint counts, n, mean ± SD
|
2.24 ± 2.09**
|
2.68 ± 1.82
|
3.03 ± 1.88
|
3.41 ± 2.49
|
2.30 ± 2.13
|
2.56 ± 1.77
|
3.02 ± 1.90
|
3.31 ± 2.47
|
Swollen joint changes, n, mean ± SD
|
−4.03 ± 3.58*
|
−3.15 ± 2.48
|
−2.17 ± 2.43
|
−2.78 ± 2.96
|
−4.38 ± 3.61*
|
−3.31 ± 2.43
|
−2.30 ± 2.37
|
−3.04 ± 3.01
|
Morning stiffness, min, mean ± SD
|
36.53 ± 24.69**
|
46.10 ± 26.57
|
50.14 ± 36.08
|
54.93 ± 41.78
|
35.00 ± 23.27**
|
45.56 ± 27.29
|
50.14 ± 36.67
|
55.21 ± 44.38
|
Morning stiffness changes, min, mean ± SD
|
−45.51 ± 34.71
|
−35.25 ± 21.40
|
−33.17 ± 28.42
|
−35.32 ± 42.23
|
−50.09 ± 33.56
|
−38.15 ± 19.96
|
−33.81 ± 28.70
|
−39.12 ± 43.33
|
Grip strength, mmHg, mean ± SD
|
47.68 ± 28.59
|
38.80 ± 24.49
|
40.58 ± 26.27
|
38.84 ± 25.12
|
47.14 ± 29.13
|
36.00 ± 23.63
|
39.63 ± 26.22
|
36.99 ± 25.07
|
Grip strength changes, mmHg, mean ± SD
|
11.57 ± 21.19**
|
6.27 ± 7.07
|
5.51 ± 10.01
|
3.97 ± 8.53
|
12.32 ± 22.21**
|
6.76 ± 6.98
|
5.70 ± 10.13
|
3.93 ± 8.75
|
Physician’s assessments, score, mean ± SD
|
2.65 ± 1.40**
|
3.32 ± 1.37
|
3.62 ± 1.34
|
3.79 ± 1.42
|
2.52 ± 1.34**
|
3.24 ± 1.37
|
3.62 ± 1.36
|
3.68 ± 1.45
|
Physician’s assessments changes, score, mean ± SD
|
−2.67 ± 1.91**
|
−2.02 ± 1.36
|
−1.45 ± 1.48
|
−1.51 ± 1.65
|
−2.92 ± 1.84**
|
−2.07 ± 1.30
|
−1.46 ± 1.49
|
−1.60 ± 1.71
|
HAQ, score, mean ± SD
|
10.31 ± 9.91
|
12.69 ± 11.05
|
11.36 ± 9.64
|
12.92 ± 11.35
|
11.19 ± 10.06
|
12.89 ± 11.25
|
11.65 ± 9.67
|
13.60 ± 11.64
|
HAQ changes, score, mean ± SD
|
−6.37 ± 8.60
|
−5.41 ± 6.98
|
−4.03 ± 5.60
|
−4.15 ± 7.90
|
−6.89 ± 8.89
|
−5.83 ± 7.13
|
−4.18 ± 5.64
|
−4.31 ± 8.13
|
RF, U/ml, mean ± SD
|
122.61 ± 194.75
|
60.55 ± 99.04
|
90.35 ± 160.68
|
64.88 ± 102.79
|
129.88 ± 203.21
|
63.42 ± 104.21
|
93.28 ± 165.28
|
67.93 ± 109.24
|
CRP, mg/dl, median ± IQR
|
12.63 ± 44.50
|
5.68 ± 10.62
|
5.48 ± 8.48
|
6.81 ± 15.15
|
14.05 ± 47.27
|
5.75 ± 11.03
|
5.78 ± 8.70
|
7.25 ± 16.20
|
ESR, mm/h, mean ± SD
|
21.24 ± 21.91
|
21.32 ± 24.15
|
22.95 ± 20.24
|
23.25 ± 19.66
|
20.69 ± 21.89
|
21.39 ± 25.25
|
23.75 ± 20.42
|
24.26 ± 20.56
|
Joint functional stage, I : II : III
|
22:37:0
|
14:44:1
|
16:40:3
|
20:37:2
|
21:32:0
|
14:39:1
|
16:38:3
|
19:32:1
|
Voltaren use : no use
|
3:56**
|
10:47**
|
20:38**
|
23:33
|
3:50**
|
9:45**
|
20:37
|
21:31
|
Frequency of Voltaren use, mean ± SD
|
7.40 ± 8.08**
|
17.80 ± 13.02**
|
22.03 ± 17.11**
|
39.32 ± 20.13
|
7.40 ± 8.08**
|
17.63 ± 13.35**
|
22.03 ± 17.11**
|
39.29 ± 20.34
|
Leflunomide use : no use
|
14:45
|
22:35
|
22:36
|
24:32
|
41:39
|
20:34
|
22:35
|
22:30
|