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Table 5 Trial B: biases and variability in the amount of injected formulations of interferon β-1a

From: Biases affecting injected doses of an experimental drug during clinical trials

Formulation TW i W i Median relative bias Route
[mg] [mg] Bias [%] Range
Biferonex® HSA-free 1497.5 1593.9 6.8 % 2.7 % Intravenous
Biferonex® HSA-free 1497.5 1608.4 7.5 % 4.8 % Subcutaneous
Biferonex® + HSA 3060.0 2918.5 −4.2 % 7.2 % Intravenous
Rebif® 1497.5 1538.7 2.9 % 2.4 % Intravenous
Rebif® 1497.5 1548.8 3.6 % 2.9 % Subcutaneous
  1. Biases evaluated during Trial B with three different formulations at a dose of 18.0 MIU. TW i = weight of solution to inject, W i = weight actually injected, bias = median of (W i − TW i)/TW i, with the range covered by individual measures