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Systematic review of outcome domains and instruments used in clinical trials of tinnitus treatments in adults

  • Deborah A. Hall1, 2Email author,
  • Haula Haider3,
  • Agnieszka J. Szczepek4,
  • Pia Lau5,
  • Sarah Rabau6,
  • Julie Jones-Diette1, 7,
  • Alain Londero8,
  • Niklas K. Edvall9,
  • Christopher R. Cederroth9,
  • Marzena Mielczarek10,
  • Thomas Fuller11, 12,
  • Angel Batuecas-Caletrio13,
  • Petra Brueggemen14,
  • Dean M. Thompson1, 2,
  • Arnaud Norena15,
  • Rilana F. F. Cima11, 12,
  • Rajnikant L. Mehta1, 2 and
  • Birgit Mazurek14

Received: 12 February 2016

Accepted: 14 May 2016

Published: 1 June 2016

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
12 Feb 2016 Submitted Original manuscript
Author responded Author comments
Reviewed Reviewer Report
Resubmission - Version 2
Submitted Manuscript version 2
14 May 2016 Editorially accepted
1 Jun 2016 Article published 10.1186/s13063-016-1399-9

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

National Institute for Health Research (NIHR) Nottingham Hearing Biomedical Research Unit
Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham
ENT Department of Hospital Cuf Infante Santo – Nova Medical School
Department of Otorhinolaryngology, Charite University Hospital
Institute of Biomagnetism and Biosignalanalysis, University Hospital Münster
Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Antwerp
Centre for Reviews and Dissemination, University of York
Service ORL et CCF, Consultation Acouphène et Hyperacousie, Hôpital Européen G. Pompidou
Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet
Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics, |Medical University of Lodz
Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University
Adelante, Centre of Expertise in Rehabilitation and Audiology
Department of Otorhinolaryngology, IBSAL, University Hospital of Salamanca
Tinnitus Center, Charite University Hospital
Laboratory of Adaptive and Integrative Neuroscience, Centre National de la Recherche Scientifique, Fédération de Recherche 3C, Aix-Marseille Université