Clinical stage 2 |
• Moderate unexplained weight loss (5–10 % of presumed or measured body weight) |
• Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media and pharyngitis) |
• Herpes zoster |
• Angular cheilitis |
• Recurrent oral ulceration |
• Papular pruritic eruptions |
• Seborrhoeic dermatitis |
• Fungal nail infections |
Clinical stage 3 |
• Unexplained severe weight loss (>10 % of presumed or measured body weight) |
• Unexplained chronic diarrhoea for longer than 1 month |
• Unexplained persistent fever (above 37.5 °C intermittent or constant, for longer than 1 month) |
• Persistent oral candidiasis |
• Oral hairy leukoplakia |
• Pulmonary tuberculosis |
• Severe bacterial infections (e.g., pneumonia, empyema, pyomyositis, bone or joint infection, bacteremia, severe pelvic inflammatory disease) |
• Acute necrotizing ulcerative stomatitis, gingivitis or periodontitis |
• Unexplained anemia (<8 g/dl), neutropenia (<500/mm3) and/or chronic thrombocytopenia (<50,000/mm3) |
Clinical stage 4 |
• HIV wasting syndrome |
• Pneumocystis jirovecii pneumonia |
• Recurrent severe bacterial pneumonia |
• Chronic herpes simplex infection (orolabial, genital or anorectal of more than 1 month’s duration or visceral at any site) |
• Oesophageal candidiasis (or candidiasis of the trachea, bronchi or lungs) |
• Extrapulmonary tuberculosis |
• Kaposi’s sarcoma |
• Cytomegalovirus infection (retinitis or infection of other organs, excluding liver, spleen or lymph nodes) |
• Central nervous system toxoplasmosis |
• HIV encephalopathy |
• Extrapulmonary cryptococcosis including meningitis |
• Disseminated nontuberculous mycobacterial infection |
• Progressive multifocal leukoencephalopathy (PML) |
• Candida of trachea, bronchi or lungs |
• Chronic cryptosporidiosis |
• Chronic isosporiasis |
• Disseminated mycosis (histoplasmosis, coccidiomycosis) |
• Recurrent septicemia (including nontyphoidal Salmonella) |
• Lymphoma (cerebral or B-cell non-Hodgkin) |
• Invasive cervical carcinoma |
• Atypical disseminated leishmaniasis |
• Symptomatic HIV-associated nephropathy or symptomatic HIV-associated cardiomyopathy |