Clinical stage 2 |
 • Moderate unexplained weight loss (5–10 % of presumed or measured body weight) |
 • Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media and pharyngitis) |
 • Herpes zoster |
 • Angular cheilitis |
 • Recurrent oral ulceration |
 • Papular pruritic eruptions |
 • Seborrhoeic dermatitis |
 • Fungal nail infections |
Clinical stage 3 |
 • Unexplained severe weight loss (>10 % of presumed or measured body weight) |
 • Unexplained chronic diarrhoea for longer than 1 month |
 • Unexplained persistent fever (above 37.5 °C intermittent or constant, for longer than 1 month) |
 • Persistent oral candidiasis |
 • Oral hairy leukoplakia |
 • Pulmonary tuberculosis |
 • Severe bacterial infections (e.g., pneumonia, empyema, pyomyositis, bone or joint infection, bacteremia, severe pelvic inflammatory disease) |
 • Acute necrotizing ulcerative stomatitis, gingivitis or periodontitis |
 • Unexplained anemia (<8 g/dl), neutropenia (<500/mm3) and/or chronic thrombocytopenia (<50,000/mm3) |
Clinical stage 4 |
 • HIV wasting syndrome |
 • Pneumocystis jirovecii pneumonia |
 • Recurrent severe bacterial pneumonia |
 • Chronic herpes simplex infection (orolabial, genital or anorectal of more than 1 month’s duration or visceral at any site) |
 • Oesophageal candidiasis (or candidiasis of the trachea, bronchi or lungs) |
 • Extrapulmonary tuberculosis |
 • Kaposi’s sarcoma |
 • Cytomegalovirus infection (retinitis or infection of other organs, excluding liver, spleen or lymph nodes) |
 • Central nervous system toxoplasmosis |
 • HIV encephalopathy |
 • Extrapulmonary cryptococcosis including meningitis |
 • Disseminated nontuberculous mycobacterial infection |
 • Progressive multifocal leukoencephalopathy (PML) |
 • Candida of trachea, bronchi or lungs |
 • Chronic cryptosporidiosis |
 • Chronic isosporiasis |
 • Disseminated mycosis (histoplasmosis, coccidiomycosis) |
 • Recurrent septicemia (including nontyphoidal Salmonella) |
 • Lymphoma (cerebral or B-cell non-Hodgkin) |
 • Invasive cervical carcinoma |
 • Atypical disseminated leishmaniasis |
 • Symptomatic HIV-associated nephropathy or symptomatic HIV-associated cardiomyopathy |