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Table 1 Design of the six-arm four-stage STAMPEDE trial in prostate cancer

From: Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes

Stage (j) Target Outcome One-sided significance Power (ω j ) Required control
  HR   level (α j )   arm events
1 0.75 FFS 0.500 0.95 113
2 0.75 FFS 0.250 0.95 216
3 0.75 FFS 0.100 0.95 334
4 0.75 OS 0.025 0.90 403
Overall    0.013 0.83  
  1. FFS failure-free survival, HR hazard ratio, OS overall survival