Design of trials for interrupting the transmission of endemic pathogens

Table 2 Power of three contemporaneous effectiveness measures at week 60, midway through the intervention rollout, type I error =10 % and efficacy E _s=30 %

r	\(\overline {y_{r}}(0)\)	Power \(\hat {e}_{4}\)	Power \(\hat {e}_{5} \)	Power \(\hat {e}_{6}\)
Hierarchical design
0.50	0.10	0.99	0.90	0.51
	0.20	0.99	0.90	0.52
	0.50	0.98	0.83	0.41
	0.80	0.85	0.59	0.18
1.00	0.10	0.83	0.82	0.67
	0.20	0.87	0.74	0.56
	0.50	0.81	0.64	0.45
	0.80	0.53	0.45	0.29
1.50	0.10	0.58	0.95	0.91
	0.20	0.59	0.86	0.78
	0.50	0.50	0.62	0.51
	0.80	0.28	0.45	0.37
Oil-drop design
0.50	0.10	0.99	0.93	0.53
	0.20	0.99	0.94	0.54
	0.50	0.98	0.88	0.41
	0.80	0.86	0.64	0.18
1.00	0.10	0.91	0.84	0.64
	0.20	0.93	0.82	0.59
	0.50	0.88	0.74	0.48
	0.80	0.60	0.52	0.28
1.50	0.10	0.75	0.84	0.63
	0.20	0.77	0.82	0.61
	0.50	0.69	0.76	0.51
	0.80	0.41	0.52	0.31
Random cluster design
0.50	0.10	0.98	0.89	0.52
	0.20	0.99	0.90	0.52
	0.50	0.97	0.83	0.40
	0.80	0.84	0.58	0.18
1.00	0.10	0.80	0.80	0.66
	0.20	0.84	0.73	0.58
	0.50	0.79	0.63	0.45
	0.80	0.50	0.44	0.29
1.50	0.10	0.54	0.94	0.88
	0.20	0.54	0.79	0.74
	0.50	0.45	0.56	0.48
	0.80	0.25	0.41	0.36

ISSN: 1745-6215