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Table 3 Comparison of the design of the three PIP studies

From: Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials

 

PIP-IVF

PIP-UE

PIP-PCOS

Standard care

IVF/ICSI/embryo transfer

No treatment

Ovulation induction medication (metformin, clomiphene,

Method of attempted conception

IVF/ICSI/embryo transfer

Intercourse

Intercourse

Randomisation timing

Approx. day 1 of cycle prior to treatment cycle

Immediately prior to the intervention

Immediately prior to the intervention

Intervention

Endometrial scratching by pipelle

Endometrial scratching by pipelle

Endometrial scratching by pipelle

Control group

No procedure

Placebo procedure

Placebo procedure

Intervention timing

Between day of the cycle prior to IVF, until day 3 of the IVF cycle

Between days 1–12 of the first study cycle

Between days 1–12 of the first study cycle

Blinding

Open label

Single-blind (participants are blind)

Single-blind (participants are blind)

Number of study cycles/opportunities to conceive

One

Three

Three

Study diary

No

Yes

Yes