From: Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials
 | PIP-IVF | PIP-UE | PIP-PCOS |
---|---|---|---|
Standard care | IVF/ICSI/embryo transfer | No treatment | Ovulation induction medication (metformin, clomiphene, |
Method of attempted conception | IVF/ICSI/embryo transfer | Intercourse | Intercourse |
Randomisation timing | Approx. day 1 of cycle prior to treatment cycle | Immediately prior to the intervention | Immediately prior to the intervention |
Intervention | Endometrial scratching by pipelle | Endometrial scratching by pipelle | Endometrial scratching by pipelle |
Control group | No procedure | Placebo procedure | Placebo procedure |
Intervention timing | Between day of the cycle prior to IVF, until day 3 of the IVF cycle | Between days 1–12 of the first study cycle | Between days 1–12 of the first study cycle |
Blinding | Open label | Single-blind (participants are blind) | Single-blind (participants are blind) |
Number of study cycles/opportunities to conceive | One | Three | Three |
Study diary | No | Yes | Yes |