CAMERA2 – combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial

Table 6 Schedule of visits, data collection and follow-up

Visit day	Pre-screen	Day 1	Day 2	Day 3	Day 4	Day 5	Day 6	Day 7	Days 8–13	Day 14	Day 15–41	Day 42	Days 43–89	Day 90
Check eligibility	x
Informed consent		x
Demographic data		x
Clinical details		x
Randomise		x
Ensure blood cultures are ordered by treating clinicians	x		x			x		(x)^a	(x)^a	(x)^a	(x)^a
Ensure FBC, EUC, LFTs, CRP and vancomycin levels are ordered by treating clinicians			x			x		x	As clinically indicated
Vancomycin or daptomycin doses		x	x	x	x	x	x	x	x	x	(x)^b	(x)^b	(x)^b
Combination therapy group: β-lactam doses		x	x	x	x	x	x	x
Clinical progress assessment			x			x		x		x	Weekly whilst in hospital			x
Vital status (alive)		x		x		x		x		x		x		x
Additional data review									x	x	x	x		x

CRP C-reactive protein, EUC electrolytes urea and creatinine, FBC full blood count, LFTs liver function tests
^aIf blood cultures are still positive at day 5, they should be recollected on day 7 and then every 48 hours until negative.
If they are negative on day 5, they should be recollected only if there is any clinical suspicion of relapse (eg. recurrent fever)
^bMinimum recommended duration of vancomycin or daptomycin is 14 days – clinicians may choose to give longer courses, typically up to 42 days

ISSN: 1745-6215