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Table 6 Schedule of visits, data collection and follow-up

From: CAMERA2 – combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial

Visit day Pre-screen Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Days 8–13 Day 14 Day 15–41 Day 42 Days 43–89 Day 90
Check eligibility x              
Informed consent   x             
Demographic data   x             
Clinical details   x             
Randomise   x             
Ensure blood cultures are ordered by treating clinicians x   x    x   (x)a (x)a (x)a (x)a    
Ensure FBC, EUC, LFTs, CRP and vancomycin levels are ordered by treating clinicians    x    x   x As clinically indicated
Vancomycin or daptomycin doses   x x x x x x x x x (x)b (x)b (x)b  
Combination therapy group: β-lactam doses   x x x x x x x       
Clinical progress assessment    x    x   x   x Weekly whilst in hospital    x
Vital status (alive)   x   x   x   x   x   x   x
Additional data review          x x x x   x
  1. CRP C-reactive protein, EUC electrolytes urea and creatinine, FBC full blood count, LFTs liver function tests
  2. aIf blood cultures are still positive at day 5, they should be recollected on day 7 and then every 48 hours until negative.
  3. If they are negative on day 5, they should be recollected only if there is any clinical suspicion of relapse (eg. recurrent fever)
  4. bMinimum recommended duration of vancomycin or daptomycin is 14 days – clinicians may choose to give longer courses, typically up to 42 days