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Table 5 Adjustment of daptomycin doses according to renal function

From: CAMERA2 – combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial

GFR Daptomycin dose
>50 ml/min 6–10 mg/kg IVI q24h
11–50 ml/min 6–8 mg/kg q24h IVI
≤10 but not on haemodialysis 8 mg/kg q48h IVI
On continuous renal replacement therapy 8 mg/kg q48h IVI
On haemodialysis 8 mg/kg q48h IVI, dose after dialysis
  1. GFR glomerular filtration rate, IVI intravenous infusion, q6/8/12h 6/8/12-hourly