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Table 5 Adjustment of daptomycin doses according to renal function

From: CAMERA2 – combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial

GFR

Daptomycin dose

>50 ml/min

6–10 mg/kg IVI q24h

11–50 ml/min

6–8 mg/kg q24h IVI

≤10 but not on haemodialysis

8 mg/kg q48h IVI

On continuous renal replacement therapy

8 mg/kg q48h IVI

On haemodialysis

8 mg/kg q48h IVI, dose after dialysis

  1. GFR glomerular filtration rate, IVI intravenous infusion, q6/8/12h 6/8/12-hourly