Author Year | Number of patients | GA (weeks) | BW (g) | Postnatal age (days) | Daily dosage/administration route | No. of PDA closure | Safety issues |
---|---|---|---|---|---|---|---|
Hammerman 2012 [13] | 5 | 26–32 | 720–1210 | 3–35 | 60 mg/kg oral | 5/5 | No toxicity observed. |
Oncel 2013 [14] | 8 | 27–34 | 630–2970 | 5–27 | 60 mg/kg oral | 7/8 | Pre-treatment and post-treatment liver enzymes were normal in all patients. |
Oncel 2013 [15] | 10 | 24–30 | 590–990 | 2–15 | 60 mg/kg intravenous | 10/10 | No adverse effects were observed. Pre-treatment and post-treatment liver enzymes were normal in all patients. |
Yurttutan 2013 [16] | 6 | 26–33 | 920–1600 | 3–7 | 60 mg/kg oral | 5/6 | No adverse side effects were observed. Pre-treatment and post-treatment liver enzymes and bilirubin were normal in all patients. |
Ozdemir 2013 [17] | 7 | 23–32 | 620–1615 | 20–47 | 60 mg/kg oral | 5/7 | No side effects, no hepatotoxicity, and no abnormalities in the hematologic and biochemical analyses. |
Sinha 2013 [18] | 10 | 27–33 | 800–1380 | 4–7 | 45 mg/kg oral | 10/10 | No side effects related to paracetamol. |
Jasani 2013 [19] | 6 | 28–31 | 1040–1235 | 2–8 | 60 mg/kg oral | 6/6 | No adverse effects. Pre-treatment and post-treatment liver enzymes were normal in all neonates. |
Kessel 2014 [20] | 7 | 26–30 | 789–1322 | not available | 60 mg/kg oral | 7/7 | No side effects related to paracetamol. |
Terrin 2014 [21] | 8 | 24–28 | 551–897 | 38–94 h | 60 mg/kg intravenous | 6/8 | No side effects related to paracetamol. |
Nadir 2014 [22] | 7 | 24–27 | 656–951 | 2–22 | 60 mg/kg oral | 5/7 | No abnormalities in hematologic and biochemical analyses. |