Outcome measures | Outcomes |
---|---|
Primary outcomes | |
HIV viral load (chart-abstracted HIV RNA) | Undetectable viral load (binary) (primary) Log change in viral load from baseline (continuous) |
Dose-taking adherence (MEMS) | Took at least 85 % of prescribed doses (binary) (primary) Percentage of prescribed doses taken (continuous) |
Secondary outcomes | |
Dose-timing adherence (MEMS) | Percentage of prescribed doses taken in correct time window (±2 h for twice-daily regimens and ±3 h for once-daily regimens) (continuous) Took at least 85 % of prescribed doses on time (binary) |
Dose-taking adherence (self-report) | Percentage of prescribed doses taken in past 7 days (continuous) Took at least 85 % of prescribed doses (binary) Visual analogue scale rating from 0 % to 100 % adherence over past 30 days |
Dose interruptions (MEMS data) | Number of >48-h interruptions |
Clinic attendance (chart abstract; self-report) | Number of attended and missed clinic appointments in past 6 months |
CD4 count (chart-abstracted) | Change from baseline |