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Table 2 Primary and secondary outcomes

From: Supporting Treatment Adherence Readiness through Training (START) for patients with HIV on antiretroviral therapy: study protocol for a randomized controlled trial

Outcome measures Outcomes
Primary outcomes
HIV viral load (chart-abstracted HIV RNA) Undetectable viral load (binary) (primary) Log change in viral load from baseline (continuous)
Dose-taking adherence (MEMS) Took at least 85 % of prescribed doses (binary) (primary) Percentage of prescribed doses taken (continuous)
Secondary outcomes
Dose-timing adherence (MEMS) Percentage of prescribed doses taken in correct time window (±2 h for twice-daily regimens and ±3 h for once-daily regimens) (continuous) Took at least 85 % of prescribed doses on time (binary)
Dose-taking adherence (self-report) Percentage of prescribed doses taken in past 7 days (continuous) Took at least 85 % of prescribed doses (binary) Visual analogue scale rating from 0 % to 100 % adherence over past 30 days
Dose interruptions (MEMS data) Number of >48-h interruptions
Clinic attendance (chart abstract; self-report) Number of attended and missed clinic appointments in past 6 months
CD4 count (chart-abstracted) Change from baseline
  1. MEMS Medication Event Monitoring System