Table 4 Reasons for early termination of a trial
From: Adaptive designs undertaken in clinical research: a review of registered clinical trials
Reason | Phase II | Phase II/III | Phase III | |||
|---|---|---|---|---|---|---|
Private | Public | Private | Public | Private | Public | |
Poor recruitment | 1 | 0 | 1 | 0 | 0 | 1 |
Efficacy | 0 | 0 | 0 | 0 | 1 | 0 |
Futility | 3 | 2 | 3 | 0 | 4 | 1 |
Safety | 0 | 0 | 0 | 0 | 0 | 1 |
Financial | 1 | 0 | 1 | 0 | 0 | 0 |
Other | 0 | 0 | 0 | 0 | 1 | 0 |
All a | 5 | 2 | 5 | 0 | 6 | 3 |