Table 3 Type of adaptation stratified by phase and funder
From: Adaptive designs undertaken in clinical research: a review of registered clinical trials
Type of adaptation | Phase II | Phase II/III | Phase III | All phases | |||
|---|---|---|---|---|---|---|---|
Private | Public | Private | Public | Private | Public | Total | |
GSD only | 10 | 6 | 0 | 2 | 10 | 10 | 38 |
SSR only | 1 | 0 | 0 | 0 | 4 | 2 | 7 |
DS | 25 | 3 | 0 | 0 | 0 | 0 | 28 |
Dose escalation (DE) | 3 | 2 | 0 | 0 | 1 | 0 | 6 |
Seamless | 0 | 0 | 3 | 1 | 0 | 0 | 4 |
GSD and SSR | 1 | 0 | 0 | 0 | 2 | 0 | 3 |
GSD and DS | 13 | 2 | 0 | 1 | 4 | 2 | 22 |
GSD and DE | 1 | 1 | 0 | 0 | 0 | 0 | 2 |
GSD and seamless | 0 | 0 | 3 | 6 | 0 | 0 | 9 |
SSR and DS | 4 | 1 | 0 | 0 | 0 | 0 | 5 |
Seamless and SSR | 0 | 0 | 3 | 2 | 0 | 0 | 5 |
Seamless and DS | 1 | 0 | 10 | 1 | 0 | 0 | 12 |
Interim analysis | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Interim analysis and SSR | 0 | 0 | 0 | 0 | 1 | 0 | 1 |