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Table 3 Type of adaptation stratified by phase and funder

From: Adaptive designs undertaken in clinical research: a review of registered clinical trials

Type of adaptation Phase II Phase II/III Phase III All phases
  Private Public Private Public Private Public Total
GSD only 10 6 0 2 10 10 38
SSR only 1 0 0 0 4 2 7
DS 25 3 0 0 0 0 28
Dose escalation (DE) 3 2 0 0 1 0 6
Seamless 0 0 3 1 0 0 4
GSD and SSR 1 0 0 0 2 0 3
GSD and DS 13 2 0 1 4 2 22
GSD and DE 1 1 0 0 0 0 2
GSD and seamless 0 0 3 6 0 0 9
SSR and DS 4 1 0 0 0 0 5
Seamless and SSR 0 0 3 2 0 0 5
Seamless and DS 1 0 10 1 0 0 12
Interim analysis 1 0 0 0 0 0 1
Interim analysis and SSR 0 0 0 0 1 0 1
  1. DE dose escalation, DS dose selection, GSD group sequential design, SSR sample size re-estimation