New carbetocin RTS formulation | Current carbetocin refrigerated formulation (Duratocin®, Ferring)a | ||||
---|---|---|---|---|---|
Component | Amount (mg/mL) | Function | Component | Amount (mg/mL | Function |
Carbetocin | 0.100 | Active substance | Carbetocin | 0.100 | Active substance |
Succinic acid | 1.19 | Buffer | Sodium chloride | 9 | Isotonicity agent |
Mannitol | 47.0 | Isotonicity agent | Glacial acetic acid | to pH 3.8 | pH adjustment |
L-methionine | 1.00 | Antioxidant | Water for injection | 1.0 mL | Solvent |
Sodium hydroxide 2 N | to pH 5.45 | pH adjustment | -- | -- | -- |
Water for injection | 1.0 mL | Solvent | -- | -- | -- |