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Table 1 Composition of carbetocin RTS and carbetocin

From: Room temperature stable carbetocin for the prevention of postpartum haemorrhage during the third stage of labour in women delivering vaginally: study protocol for a randomized controlled trial

New carbetocin RTS formulation

Current carbetocin refrigerated formulation (Duratocin®, Ferring)a

Component

Amount (mg/mL)

Function

Component

Amount (mg/mL

Function

Carbetocin

0.100

Active substance

Carbetocin

0.100

Active substance

Succinic acid

1.19

Buffer

Sodium chloride

9

Isotonicity agent

Mannitol

47.0

Isotonicity agent

Glacial acetic acid

to pH 3.8

pH adjustment

L-methionine

1.00

Antioxidant

Water for injection

1.0 mL

Solvent

Sodium hydroxide 2 N

to pH 5.45

pH adjustment

--

--

--

Water for injection

1.0 mL

Solvent

--

--

--

  1. aCarbetocin 100 μg/mL was first approved in Canada in June 1997 and is currently registered in more than 70 countries under the trade names PABAL/DURATOCIN/LONACTENE/DURATOBAL
  2. RTS room temperature stable