| | | |
During CPBa
| | | | | |
|---|
| |
Hospital admission
|
Baseline
|
10 min
|
30 min
|
60 min
|
ICU admission
|
ICU d 1
|
ICU d 2
|
ICU d 3-28
|
Follow-up (hospital discharge)
|
|---|
|
Routine blood samples
|
X
|
X
| | | |
X
|
X
|
X
|
X
|
X
|
|
IL-6
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
IL-2
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
IL-8
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
IL-10
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
TNF-alpha
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
C3a
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Free haemoglobin
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Haptoglobin
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Myoglobin
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Fibrinogen
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Syndecan-1
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Hyaluronan
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Heparan sulphate
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
|
Markers of mast cell degranulation
| |
X
|
X
|
X
|
X
|
X
|
X
|
X
| | |
-
aIntraoperative cytokine kinetics and markers of secondary objectives will only be assessed in patients allocated to the haemoadsorption device at 10, 30 and 60 min after initiation of cardiopulmonary bypass (CPB). For this, blood samples at the defined time points will be taken from the CPB circuit both before and after use of the haemoadsorption device
