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Table 2 Sample size estimation based on four scenarios with small to medium effect sizes

From: Effectiveness and cost-effectiveness of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care: study protocol for a randomised controlled trial

Scenario Effect size (d) ICC Standard care Intervention Time points Alpha Tails Power
Scenario 1 0.25 0.3 115 115 4 0.05 2 0.80
Scenario 2 0.3 0.3 80 80 4 0.05 2 0.80
Scenario 3 0.35 0.3 59 59 4 0.05 2 0.80
Scenario 4 0.4 0.3 46 46 4 0.05 2 0.81