Skip to main content
Fig. 1 | Trials

Fig. 1

From: Early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury (The ELAIN-Trial): study protocol for a randomized controlled trial

Fig. 1

Trial workflow. Patients will be identified for recruitment by screening all patients receiving care in the ICU on a daily basis. Before enrolment, the fluid status is analyzed in cooperation with the attending physicians and optimized if necessary. After optimization is ensured, informed consent is obtained and the patient will be registered by randomization. Before initiating RRT, laboratory tests will be performed and different variables will be documented. In the ‘early’ group, RRT will be initiated immediately after randomization, whereas initiation of RRT in the ‘late’ group will be started only after reaching stage 3 of the KDIGO classification and/or if absolute indications for RRT are present. Patients randomized to ‘late’ but never reaching stage 3 will remain in the ‘late’ group for purposes of analysis. Laboratory tests will be analyzed and variables relevant for the assessment of illness severity will be recorded on day 1 to day 21, day 28, day 60, day 90 and 1 year

Back to article page