Table 1 Distribution fitting for processing times at each sub-process and activity in the administrative process associated with industry-sponsored clinical trial activation at the University of South Florida. In the simulation software Arena, the default random number stream 10 was used to generate the duration of each sub-process
From: Activating clinical trials: a process improvement approach
Subprocess (activity) | Squared error | Parameters | Arena random number stream |
|---|---|---|---|
Initial Preparation | |||
OCR sends documents | - | Uniform (0.5, 1.0)a | 10 |
P&L reviews | - | Triangular (1.0, 8.0, 21.0)a | 10 |
PI prepares documents | - | Triangular (1.0, 2.0, 3.0) | 10 |
P&L reviews | - | Uniform (0.5, 1.0) | 10 |
Contract Negotiation | 0.01 | Exponential (28.5) | 10 |
Budget Negotiation | 0.01 | Exponential (25.0) | 10 |
PI Approval | 0.02 | Lognormal (5.0, 8.3) | 10 |
DSR Approval | 0.02 | Lognormal (2.5, 2.8) | 10 |
Sponsor | 0.02 | Lognormal (6.5, 15.9) | 10 |