Table 4 Overall consistency and discrepancy between protocols and corresponding published reports by published report-derived type of study, N = 143 published reports
From: From protocol to published report: a study of consistency in the reporting of academic drug trials
Exploratory published reports N = 96 | Confirmatory published reports N = 47 | Crude OR | Adjusted OR# | |||
|---|---|---|---|---|---|---|
n | % (95 % CI) | n | % (95 % CI) | OR (95 % CI) | OR (95 % CI) | |
Overall consistency | 53 | 55 % (45 to 65 %) | 17 | 36 % (22 to 50 %) | 0.46 (0.22 to 0.94) | 0.37 (0.17 to 0.83) |
Individual discrepancies | ||||||
Type of study | 17 | 18 % (10 to 25 %) | 6 | 13 % (3 to 22 %) | 0.68 (0.25 to 1.87) | 0.64 (0.21 to 1.48) |
Primary objective | 21 | 22 % (14 to 30 %) | 5 | 11 % (2 to 19 %) | 0.43 (0.15 to 1.21) | 0.56 (0.11 to 2.80) |
Primary endpoint | 34 | 35 % (26 to 45 %) | 13 | 28 % (15 to 40 %) | 0.70 (0.32 to 1.50) | 0.68 (0.31 to 1.48) |