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Table 3 Blood parameters analysed in the National Safety Associates nutritional supplementation trial of fruit and vegetable extracts and vascular function (NNTV) study

From: National Safety Associates nutritional supplementation trial of fruit and vegetable extracts and vascular function (NNTV): study protocol for a randomised controlled trial

 

Biological parameter

Screening visit

Test visit 1 (week 0)

Intermediate visit (week 6)

Test visit 2 (week 12)

Screening/Safety and Research

FBC

X

X

-

X

HbA1c

X

X

-

X

HDL

X

X

-

X

LDL

X

X

-

X

Total cholesterol

X

X

-

X

Liver function (ALT)

X

X

-

X

Creatinine

X

X

-

X

Fasting glucose

X

X

-

X

Potassium

X

X

-

X

Research

Oxidized LDL

 

X

-

X

C-Peptide

 

X

-

X

Fasting insulin

 

X

-

X

Apo A1

 

X

-

X

Apo A2

 

X

-

X

Apo B

 

X

-

X

Apo E

 

X

-

X

Cholesterol esters

 

X

-

X

Oxysterols

 

X

-

X

Isoprostanes

 

X

-

X

P-Selectin

 

X

-

X

E-Selectin

 

X

-

X

IgM phosphorylcholine

 

X

-

X

Vitamin A

 

X

X

X

Vitamin C

 

X

X

X

Vitamin E

 

X

X

X

Carotenoids

 

X

X

X

TMAOd

 

X

-

X

LPSe

 

X

-

X

DNA, Metabolomics and other relevant stored sample analyses

 

X

-

X

Urine

 

Xa, b

-

Xa, b

  1. (1). All screening bloods will be analysed at the Clinical Biochemistry and Immunology Laboratory at Addenbrooke’s Hospital. (2). Participants may be excluded from the study if screening/safety blood results are deranged. Spot urine collection: a24 hour urine collection: b(3) Additional 15-ml blood samples will be collected at test visit 1 for future DNA analysis and at test visit 2 for open profile metabolomics. FBC, full blood count; HDL, high density lipoprotein; LDL, low density lipoprotein; dTMAO, trimethylamine-N-oxide; eLPS, lipopolysaccharide