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Fig. 6 | Trials

Fig. 6

From: Effects of the pattern of glucocorticoid replacement on neural processing, emotional reactivity and well-being in healthy male individuals: study protocol for a randomised controlled trial

Fig. 6

Optimised metyrapone treatment and subcutaneously pulsatile hydrocortisone replacement. Plasma 24-hour cortisol and corticotrophin (ACTH) profiles of one individual participating in study stage 1. The subject received the optimal metyrapone (Fig. 4, participant C) along with hydrocortisone substitution therapy, subcutaneously (SC), in a pulsatile manner via Crono P® pump (CANE Applied Medical Technology Ltd, Cambridge, UK). The pattern of pulsatile SC hydrocortisone administration is presented in Table 3; pulses are also indicated as black arrows in the figure. Corresponding dose of hydrocortisone is indicated above each arrow (adding up to 19.9 mg/day). This mode of hydrocortisone replacement tries to approximate the physiological (normal circadian and underlying ultradian) profile of endogenous cortisol secretion. ACTH fluctuations within normal values confirm the physiological state of the hypothalamic-pituitary-adrenal axis

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Trials

ISSN: 1745-6215