Primary outcome |
 Cumulative mortality to 28 days for the transfusion strategy comparison, and to 180 days for the nutritional support/antibiotic prophylaxis comparison |
Secondary outcomes |
 Mortality: at 48 hours, 28 days, 90 days and 180 days (cumulative) where not the primary outcome |
 Morbidity: endpoints relating to the specific mechanisms of action of each intervention: |
  re-admission to hospital |
  haematological: |
  proportion achieving correction of anaemia (defined by the WHO as Hb > 9 g/dl) at 48 hours, 28 days, 90 days and 180 days |
  development of new profound anaemia (Hb < 4 g/dl) during acute admission or development of severe anaemia (Hb < 6 g/dl) post discharge |
  nutritional: changes in weight and mid-upper arm circumference (MUAC) at 90 days and 180 days |
  anti-infection: changes in inflammatory markers (C-reactive protein (CRP) , procalcitonin), incidence of bacterial infections and malaria at 28 days, 90 days and 180 days |
  solicited adverse events: suspected transfusion reactions: febrile reactions, TRALI (Transfusion Related Acute Lung Injury) (any grade); grade 3–4 toxicity of cotrimoxazole, MVMM or standard iron/folate |
  serious adverse events |
  costs and cost-effectiveness |