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Table 4 Univariate analysis of factors influencing patients’ views on whether they would participate in a trial involving a research biopsy

From: Patients’ willingness to participate in clinical trials and their views on aspects of cancer research: results of a prospective patient survey

Patient characteristic Yes Odds ratio (95 % CI) p valuea
N (%)
(n = 78)
Age    
  < 65 years 37 (57 %) 1.0  
  ≥ 65 years 41 (67 %) 1.55 (0.75–3.21) 0.236
Gender    
 Male 59 (64 %) 1.0  
 Female 19 (56 %) 0.71 (0.32–1.58) 0.398
Tumour type    
 Colorectal 30 (60 %) 1.0  
 Oesophagogastric 37 (73 %) 1.76 (0.76–4.06) 0.184
Performance status (PS)    
 0 30 (67 %) 1.0  
 1 36 (59 %) 0.72 (0.32–1.61) 0.423
 2 7 (70 %) 1.17 (0.26-5.16) 0.839
Previously participated in a clinical trial    
 Yes 13 (65 %) 1.0  
 No 64 (61 %) 1.19 (0.44–3.23) 0.733
Number of previous lines of treatment    
 0 24 (47 %) 1.0  
 1 31 (67 %) 2.33 (1.02–5.31) 0.045
 2+ 22 (79 %) 4.13 (1.43–11.9) 0.009
Type of treatment    
 Palliative 60 (69 %) 1.0  
 Curative 18 (46 %) 0.39 (0.18–0.84) 0.015
CTIMP    
 No 44 (60 %) 1.0  
 Yes 19 (53 %) 0.74 (0.33–1.65) 0.457
  1. ap values compare the proportion of patients who answered ‘yes’: e.g. 67 % for PS0 versus 59 % for PS1 and 70 % for PS2
  2. Key: CTIMP = Clinical Trial of an Investigational Medicinal Product, pre-screening = molecular pre-screening to determine potential eligibility for a specific CTIMP study