RCT eligible | RCT not eligible | |||||||
---|---|---|---|---|---|---|---|---|
Adverse events (AEs) at 1 year | RCT(+) AZL-M | RCT(+) rami | Mean difference (95 % CI) | P-value | RCT(−) AZL-M | RCT(−) rami | Mean difference (95 % CI) | P-value |
Death, % (95 % CI) | 0.4 (0.1–1.1) | 0.0 | n.a. | 0.23 | 0.5 (0.2–1.0) | 0.3 (0.0–1.5) | n.a. | 0.61 |
Patients without AE, % | 94.0 | 94.9 | n.a. | 0.53 | 92.0 | 91.0 | n.a. | 0.51 |
Patients with any AE, % | 6.0 | 5.1 | n.a. | 0.53 | 8.0 | 9.0 | n.a. | 0.51 |
Laboratory values | ||||||||
∆ HbA1c, % | 0.02 ± 0.78 | 0.15 ± 0.72 | −0.13 (−0.40–0.14) | 0.35 | 0.01 ± 1.10 | 0.08 ± 1.06 | −0.07 (−0.39–0.25) | 0.69 |
∆ Glucose fasting, mg/dl | 5.76 ± 77.68 | 1.90 ± 19.59 | 3.85 (−23.65–31.4) | 0.91 | 0.12 ± 21.13 | 2.81 ± 15.17 | −2.69 (−10.70–5.32) | 0.37 |
∆ Creatinine, mg/dl | 0.04 ± 0.17 | 0.01 ± 0.20 | 0.03 (−0.02–0.08) | 0.09 | −0.06 ± 1.06 | −0.10 ± 1.14 | 0.04 (−0.22–0.31) | 0.90 |
∆ Potassium, mmol/L | 0.05 ± 0.39 | 0.04 ± 0.53 | 0.02 (−0.16–0.20) | 0.69 | 0.00 ± 0.51 | 0.08 ± 0.54 | −0.08 (−0.25–0.09) | 0.42 |
∆ GFR, ml/min/1.73 m2 | −2.26 ± 10.10 | −0.05 ± 11.58 | −2.21 (−5.26–0.84) | 0.11 | −1.45 ± 14.15 | −1.08 ± 14.90 | −0.37 (−3.86–3.12 ) | 0.69 |