Table 3 Blood pressure reductions: comparison of treatment groups (AZL-M versus ramipril) by RCT eligibility in those with 12-mo. follow-up

 Δ Systolic, mmHg

29.9 (29.0–30.9)

27.1 (25.4–28.7)

2.8 (1.1–4.7)

<0.01

22.7 (21.5–23.9)

18.9 (16.9–21.0)

3.8 (1.3–6.3)

<0.01

 Δ Diastolic, mmHg

14.7 (14.1–15.3)

12.5 (11.4–13.6)

2.2 (1.0–3.4)

<0.01

11.6 (10.9–12.3)

10.7 (9.4–12.0)

0.9 (−0.6–2.5)

0.07

 Δ Mean pressure, mmHg

19.8 (19.2–20.4)

17.4 (16.3–18.5)

2.4 (1.2–3.6)

<0.001

15.3 (14.5–16.1)

13.4 (12.1–14.8)

1.9 (0.2–3.5)

<0.01

 Δ Pulse pressure, mmHg

15.2 (14.4–16.1)

14.5 (13.1–16.0)

0.7 (−1.0–2.4)

0.37

11.1 (10.1–12.1)

8.3 (6.5–10.0)

2.8 (0.7–5.0)

<0.05

 Δ Heart rate, bpm

3.9 (3.4–4.4)

3.7 (2.9–4.5)

0.7 (−0.7–2.0)

0.45

2.3 (1.6–2.9)

2.2 (1.1–3.4)

0.1 (−1.3–1.3)

0.79

 BP <140/90 mmHg, %

64.1 (61.0–67.2)

56.1 (50.7–61.3)

n.a.

<0.01

58.7 (55.9–61.5)

57.7 (52.4–62.8)

n.a.

0.73

 Δ Systolic, mmHg

29.7 (28.9–30.4)

27.8 (26.5–29.0)

1.9 (0.4–3.4)

<0.05

22.0 (21.3–22.7)

21.6 (20.2–22.9)

0.4 (−1.1–1.9)

0.58

 Δ Diastolic, mmHg

14.5 (14.1–15.0)

13.0 (12.2–13.8)

1.5 (0.6–2.5)

<0.01

11.4 (10.9–11.8)

11.6 (10.7–12.4)

−0.2 (−1.2–0.8)

0.68

 Δ Mean pressure, mmHg

19.6 (19.0–20.1)

17.9 (17.0–18.7)

1.7 (0.7–2.6)

<0.001

15.0 (14.4–15.4)

15.0 (14.0–15.8)

0.0 (−1.0–1.0)

0.99

 Δ Pulse pressure, mmHg

15.1 (14.5–15.8)

14.7 (13.7–15.9)

0.4 (−0.9–1.7)

0.57

10.6 (10.0–11.2)

10.0 (8.8–11.2)

0.6 (−0.7–2.0)

0.35

 Δ Heart rate, bpm

3.9 (3.4–4.4)

3.7 (2.9–4.5)

0.2 (−0.7–1.1)

0.65

2.3 (1.9–2.8)

2.0 (1.2–2.8)

0.3 (−0.6–1.3)

0.48

 BP <140/90 mmHg, %

64.1 (61.1–67.1)

56.0 (50.8–61.1)

n.a.

<0.01

58.7 (55.9–61.5)

56.6 (51.4–61.7)

n.a.

0.38

 Δ Systolic, mmHg

29.7 (28.9–30.5)

27.7 (26.4–28.9)

2.0 (0.6–3.5)

<0.01

22.0 (21.3–22.7)

21.4 (20.1–22.7)

0.6 (−0.9–2.1)

0.43

 Δ Diastolic, mmHg

14.5 (14.0–15.0)

13.1 (12.3–13.9)

1.4 (0.5–2.4)

<0.01

11.1 (10.9–11.8)

11.6 (10.7–12.4)

−0.2 (−1.1–0.8)

0.67

 Δ Mean pressure, mmHg

19.6 (19.1–20.1)

17.9 (17.1–18.8)

1.6 (0.7–2.6)

<0.01

14.9 (14.4–15.4)

14.8 (14.0–15.7)

0.1 (−0.9–1.1)

0.91

 Δ Pulse pressure, mmHg

15.2 (14.6–15.9)

14.6 (13.5–15.7)

0.6 (−0.6–1.9)

0.35

10.7 (10.0–11.3)

9.8 (8.7–11.0)

0.8 (−0.5–2.1)

0.22

 Δ Heart rate, bpm

3.9 (3.4–4.4)

3.7 (2.9–4.5)

0.2 (−0.7–1.1)

0.66

2.3 (1.9–2.8)

2.0 (1.2–2.8)

0.3 (−0.6–1.3)

0.47

 BP <140/90 mmHg, %

64.4 (61.3–67.4)

55.7 (50.4–60.9)

n.a.

<0.01

59.4 (56.7–62.2)

56.3 (51.0–61.5)

n.a.

0.30