Primary outcome parameters | Instrument for data collection |
---|---|
 Overall peak external frontal knee moment and impulse | 3D gait analysis during walking |
Secondary outcome parameters | |
 Frontal and sagittal kinematics and kinetics for hip, knee and ankle joints | 3D gait analysis during walking and stair climbing |
 KOOS subscales (Austrian-German version) | Knee function in daily living (ADL) |
Knee function in sport and recreation (Sport/Rec) | |
Knee-related quality of life (QOL) | |
Knee pain and other symptoms | |
 Changes of function and strength of the targeted muscle groups | Physical examination/orthopaedic status |
 Adherence to training programme | Percentage of completed sessions among the number of intended exercise sessions |
 Ratings of knee-related pain | 7-point ordinal scale (followed for the duration of the intervention) |
Other outcome parameters | |
 Cardiopulmonary testing | Symptom-limited cardiopulmonary exercise testing on a cycle ergometer |
 Anthropometry | Anthropometric measurements |
 Body composition | Bioimpedance analysis |
 Nutritional status | 24-hour recall method (daily, self-reported consumption of food-intake) |
 Psychological status | AD-EVA test inventory, Child Behaviour Checklist (CBCL/4-18 ) |
 Blood samples | Growth hormones (GH, IGFBP3, AP) and inflammation (procalcin, TGF-α, IL-8) from venous blood samples |
All measures will be recorded at baseline and follow-up unless stated otherwise |