Evaluating the effects of Danhong injection in treatment of acute ischemic stroke: study protocol for a multicenter randomized controlled trial

Table 1 Data collection schedule and measures

Period	Run-in period	Treatment period		Follow-up period
Day	0	7 ± 2	14 ± 2	30 ± 5	60 ± 5	90 ± 3
Informed consent	×
Inclusion/exclusion criteria	×
Medical history	×
UCG	×
TOAST	×
Medical examination	×	×	×	×	×	×
Concomitant medications	×	×	×	×	×	×
Outcomes
BI scale	×	×	×	×	×	×
mRS scale	×	×	×	×	×	×
NIHSS	×	×	×	×	×	×
Chinese medicine symptom scales of “Xueyu Zheng”	×	×	×	×	×	×
EQ-5D scale	×	×	×	×	×	×
Global disability on mRS						×
New-onset major vascular events						×
Overall mortality						×
Incidence of severe hemorrhages						×
Incidence of moderate hemorrhages						×
AEs and SAEs						×
Profiles of microRNA in 60 patients from certain centers	×		×			×
Profiles of mRNA in 60 patients from certain centers	×		×			×

UCG ultrasound cardiogram, TOAST Trial of Org 10 172 in Acute Stroke Treatment, BI Barthel Index, mRS modified Rankin Scale, NIHSS National Institutes of Health Stroke Scale, AEs adverse events, SAEs serious adverse events, microRNA micro-ribonucleic acid, mRNA messenger ribonucleic acid

ISSN: 1745-6215