Table 1 Estimation of the success rate of medical abortion after two doses of misoprostol under different scenarios for the rates of the main event medical abortion, the competing event surgical abortion, and censored data ({1}–{8}), using the binomial approach ({9}, {14}), the Kaplan-Meier (KM) approach ({10}, {15}), the Life Table (LT) approach ({11}, {16}), and the competing risk survival approach ({12}, {13}, {17}, {18})
Rate of main event with 1st dose | Rate of main event with 2nd dose (a) | Rate of competing event and censoring (b) | Assumptions for number of main events (medical abortions (r1, r2), competing events (d1, d2), and censored observations (c1, c2)). | POINT ESTIMATION | STANDARD ERROR | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{1} | {2} | {3} | {4} | {5} | {6} | {7} | {8} | {9} | {10} | {11} | {12} | {13} | {14} | {15} | {16} | {17} | {18} | |||
n1 | r1 | d1 | c1 | n2 | r2 | d2 | c2 | bin | KMc | LTc | CI1(2) | CI2(2) | bin | KMc | LTc | CI1(2) | CI2(2) | |||
Low (70 %) | Low (62 %) | Low | 1000 | 700 | 15 | 14 | 271 | 168 | 102 | 1 | 86.79 % | 88.60 % | 93.20 % | 87.67 % | 12.23 % | 1.07 % | 1.04 % | 0.90 % | 1.03 % | 1.03 % |
Medium | 1000 | 700 | 30 | 27 | 243 | 151 | 91 | 1 | 85.07 % | 88.64 % | 93.47 % | 86.78 % | 13.11 % | 1.13 % | 1.08 % | 0.91 % | 1.06 % | 1.06 % | ||
High | 1000 | 700 | 60 | 48 | 192 | 119 | 72 | 1 | 81.90 % | 88.59 % | 93.90 % | 84.87 % | 15.00 % | 1.22 % | 1.19 % | 0.95 % | 1.11 % | 1.11 % | ||
High (66 %) | Low | 1000 | 700 | 15 | 14 | 271 | 179 | 91 | 1 | 87.89 % | 89.82 % | 94.08 % | 88.82 % | 11.07 % | 1.03 % | 0.99 % | 0.83 % | 0.99 % | 0.99 % | |
Medium | 1000 | 700 | 30 | 27 | 243 | 160 | 82 | 1 | 86.04 % | 89.75 % | 94.24 % | 87.78 % | 12.11 % | 1.10 % | 1.04 % | 0.85 % | 1.02 % | 1.02 % | ||
High | 1000 | 700 | 60 | 48 | 192 | 127 | 65 | 0 | 82.67 % | 89.84 % | 94.70 % | 85.87 % | 14.12 % | 1.20 % | 1.14 % | 0.88 % | 1.08 % | 1.08 % | ||
Medium (80 %) | Low (70 %) | Low | 1000 | 800 | 10 | 10 | 180 | 126 | 53 | 1 | 92.60 % | 94.00 % | 96.61 % | 93.30 % | 6.59 % | 0.83 % | 0.78 % | 0.63 % | 0.78 % | 0.78 % |
Medium | 1000 | 800 | 20 | 18 | 162 | 113 | 48 | 1 | 91.34 % | 93.95 % | 96.71 % | 92.56 % | 7.33 % | 0.89 % | 0.82 % | 0.64 % | 0.82 % | 0.81 % | ||
High | 1000 | 800 | 40 | 32 | 128 | 90 | 38 | 0 | 88.96 % | 94.06 % | 97.03 % | 91.25 % | 8.75 % | 0.99 % | 0.89 % | 0.65 % | 0.87 % | 0.87 % | ||
High (75 %) | Low | 1000 | 800 | 10 | 10 | 180 | 135 | 45 | 0 | 93.50 % | 95.00 % | 97.26 % | 94.25 % | 5.75 % | 0.78 % | 0.72 % | 0.56 % | 0.73 % | 0.73 % | |
Medium | 1000 | 800 | 20 | 18 | 162 | 122 | 40 | 0 | 92.15 % | 95.03 % | 97.39 % | 93.45 % | 6.55 % | 0.85 % | 0.75 % | 0.57 % | 0.77 % | 0.77 % | ||
High | 1000 | 800 | 40 | 32 | 128 | 96 | 32 | 0 | 89.60 % | 95.00 % | 97.57 % | 92.00 % | 8.00 % | 0.97 % | 0.83 % | 0.59 % | 0.83 % | 0.83 % | ||
High (90 %) | Low (79 %) | Low | 1000 | 900 | 5 | 5 | 90 | 71 | 19 | 0 | 97.13 % | 97.89 % | 98.87 % | 97.49 % | 2.51 % | 0.53 % | 0.47 % | 0.36 % | 0.49 % | 0.49 % |
Medium | 1000 | 900 | 10 | 9 | 81 | 64 | 17 | 0 | 96.40 % | 97.90 % | 98.93 % | 97.11 % | 2.89 % | 0.59 % | 0.49 % | 0.36 % | 0.52 % | 0.52 % | ||
High | 1000 | 900 | 20 | 16 | 64 | 51 | 13 | 0 | 95.06 % | 97.97 % | 99.06 % | 96.37 % | 3.62 % | 0.69 % | 0.54 % | 0.36 % | 0.57 % | 0.57 % | ||
High (85 %) | Low | 1000 | 900 | 5 | 5 | 90 | 77 | 13 | 0 | 97.65 % | 98.56 % | 99.26 % | 98.13 % | 1.87 % | 0.48 % | 0.40 % | 0.29 % | 0.42 % | 0.42 % | |
Medium | 1000 | 900 | 10 | 9 | 81 | 69 | 12 | 0 | 96.89 % | 98.52 % | 99.27 % | 97.67 % | 2.33 % | 0.55 % | 0.42 % | 0.30 % | 0.47 % | 0.47 % | ||
High | 1000 | 900 | 20 | 16 | 64 | 54 | 10 | 0 | 95.44 % | 98.44 % | 99.29 % | 96.75 % | 3.25 % | 0.66 % | 0.48 % | 0.31 % | 0.54 % | 0.54 % | ||