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Table 3 Baseline clinical characteristics. Data are number (%), median [interquartile range] or mean (standard deviation)

From: Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST)

 

With valid data

All/BP

IS/lipids

ICH

Number

83

83

77

6

Age (years) +

83

74.0 (6.8)

74.3 (6.6)

70.8 (8.4)

 >75 (%)

83

42 (50.6)

39 (50.6)

3 (50.0)

Sex, male (%) +

83

64 (77.1)

61 (79.2)

3 (50)

Time to randomisation [months] +

83

4.5 [1.3]

4.5 [1.2]

3.8 [1.7]

 <4 (%)

83

21 (25.3)

17 (22.1)

4 (66.7)

Medical history (%)

    

 Memory problem

77

34 (44.2)

30 (42.3)

4 (66.7)

 If yes, length (months)

34

4.8 (2.7)

4.9 (2.9)

4.3 (1.5)

Depression, recent

83

4 (4.8)

4 (5.2)

0 (0.0)

Hypertension, treated

    

 Pre-index stroke

83

51 (61.4)

47 (61.0)

4 (66.7)

 Post-index stroke

83

18 (21.7)

16 (20.8)

2 (33.3)

 Neither

83

14 (16.9)

14 (18.2)

0 (0.0)

Hypertension treated with

    

 Life style measures only

69

0 (0.0)

0 (0.0)

0 (0.0)

 Medications only

69

36 (52.2)

34 (54.0)

2 (33.3)

 Both

69

30 (43.5)

26 (41.3)

4 (66.7)

 Neither

69

3 (4.3)

3 (4.8)

0 (0.0)

Hyperlipidaemia

83

73 (88.0)

68 (88.3)

5 (83.3)

 Life style measures only

73

1 (1.4)

0 (0.0)

1 (20.0)

 Medications only

73

46 (63.0)

44 (64.7)

2 (40.0)

 Both

73

24 (32.9)

22 (32.4)

2 (40.0)

 Neither

73

2 (2.7)

2 (2.9)

0 (0.0)

Diabetes mellitus

83

17 (20.5)

16 (20.8)

1 (16.7)

Atrial fibrillation

83

15 (18.1)

15 (19.5)

0 (0.0)

Stroke

83

8 (9.6)

8 (10.4)

0 (0.0)

Transient ischaemic attack

83

16 (19.3)

15 (19.5)

1 (16.7)

Ischaemic heart disease

83

20 (24.1)

19 (24.7)

1 (16.7)

Myocardial infarction

83

11 (13.3)

11 (14.3)

0 (0.0)

Angina

83

18 (21.7)

17 (22.1)

1 (16.7)

Peripheral artery disease

83

5 (6.0)

5 (6.5)

0 (0.0)

Young stroke in first degree

83

10 (12.0)

10 (13.0)

0 (0.0)

Relative smoking (%)

    

 Current

83

5 (6.0)

5 (6.5)

0 (0.0)

 Past

83

51 (61.4)

48 (62.3)

3 (50.0)

 Never

83

27 (32.5)

24 (31.2)

3 (50.0)

Alcohol (%)

    

 >21

83

3 (3.6)

3 (3.9)

0 (0.0)

 <21

83

56 (67.5)

52 (67.5)

4 (66.7)

 None

83

24 (28.9)

22 (28.6)

2 (33.3)

Median [upw]

83

3 [0, 10]

4 [0, 10]

1 [0, 1]

BP tablets (%) +

    

 0

83

14 (16.9)

14 (18.2)

0 (0.0)

 1

83

28 (33.7)

25 (32.5)

3 (50.0)

 2

83

29 (34.9)

28 (36.4)

1 (16.7)

 3

83

11 (13.3)

9 (11.7)

2 (33.3)

 > = 4

83

1 (1.2)

1 (1.3)

0 (0.0)

Median [IQR]

83

1 [1, 2]

1 [1, 2]

1.5 [1, 3]

Lipid tablets (%)

    

 Any statin +

83

79 (95.2)

75 (97.4)

4 (66.7)

 Atorvastatin

79

21 (26.6)

19 (25.3)

2 (50.0)

 Fluvastatin

79

1 (1.3)

1 (1.3)

0 (0.0)

 Rosuvastatin

79

2 (2.5)

2 (2.7)

0 (0.0)

 Simvastatin

79

55 (69.6)

53 (70.7)

2 (50.0)

Pre-morbid mRS (%) + mRS 0

83

20 (24.1)

18 (23.4)

2 (33.3)

mRS 1

83

40 (48.2)

37 (48.1)

3 (50.0)

 mRS 2

83

19 (22.9)

18 (23.4)

1 (16.7)

 mRS > 2 ^

83

4 (4.8)

4 (5.2)

0 (0.0)

 Mean (SD)

83

1.08 (0.8)

1.10 (0.8)

0.83 (0.8)

Hand dominance (%) Right

83

76 (91.6)

70 (90.9)

6 (100.0)

 Left

83

6 (7.2)

6 (7.8)

0 (0.0)

 Both

83

1 (1.2)

1 (1.3)

0 (0.0)

Side of weakness, left (%)

63

32 (50.8)

30 (50.0)

2 (66.7)

NIHSS (%) Mean (SD) +

83

0.77 (1.1)

0.78 (1.1)

0.67 (0.8)

 Median [IQR]

83

0 [0,1]

0 [0,1]

0.5 [0,1]

OCSP classification (%) Total anterior +

83

6 (7.2)

6 (7.8)

0 (0.0)

 Partial anterior

83

36 (43.4)

32 (41.6)

4 (66.7)

 Lacunar

83

34 (41.0)

32 (41.6)

2 (33.3)

 Posterior

83

7 (8.4)

7 (9.1)

0 (0.0)

Addenbrooke's Cognitive Exam-R +

83

86.1 (7.7)

86.0 (7.6)

87.5 (9.9)

MMSE

83

27.9 (2.0)

27.9 (1.9)

27.7 (2.7)

Telephone MMSE

83

20.4 (1.8)

20.4 (1.7)

20.3 (2.7)

Montreal Cognitive Assessment

83

24.0 (2.6)

24.1 (2.6)

22.7 (2.5)

TICS-M

83

24.1 (4.2)

24.3 (4.2)

22.2 (2.6)

Stroop: Part 1 time (sec)

83

54.7

54.6 (20.5)

55.5 (23.6)

Stroop: Part 1 score

83

(20.6) 0.97 (0.0)

0.97 (0.0)

0.99 (0.0)

Stroop: Part 2 time (sec)

83

46.1

46.0 (19.9)

46.6 (31.5)

Stroop: Part 2 score

83

(20.7) 0.97 (0.0)

0.97 (0.0)

0.96 (0.1)

Stroop: Part 3 time (sec)

83

66.9

67.3 (34.8)

62.2 (32.9)

Stroop: Part 3 score

83

(34.5) 0.83 (0.2)

0.83 (0.2)

0.79 (0.3)

Stroop: Interference time (Parts 3-2) (sec)

83

20.9

21.3 (22.3)

15.6 (21.2)

Stroop - Interference score (Parts 32)

83

(22.1) -0.14 (0.2)

-0.14 (0.2)

-0.17 (0.3)

Trail making A time (sec)

83

57.1

58.1 (30.7)

43.7 (12.0)

Trail making A score

83

(30.0) 24.6 (2.8)

24.6 (2.9)

25.0 (0.0)

Trail making B time (sec)

83

155.5

151.5

207.2

Trail making B score

83

(90.8) 22.1 (5.5)

(78.9) 21.9 (5.7)

(192.6) 24.8 (0.4)

IQCODE (from informant)

83

3.0 (0.5)

3.0 (0.5)

3.2 (0.2)

Systolic BP (mmHg) +

83

147.1

147.7

139.8

 <140 (%)

83

(18.6) 32 (38.6)

(18.6) 30 (39.0)

(18.3) 2 (33.3)

 <125 (%)

83

9 (10.8)

8 (10.4)

1 (16.7)

Diastolic BP (mmHg)

83

82.1 (11.1)

82.3 (11.1)

80.1 (13.1)

Heart rate (bpm)

83

71.5 (14.2)

71.7 (14.1)

69.5 (16.7)

Lipids (mmol/L)

    

Total cholesterol +

83

4.0 (0.8)

4.0 (0.8)

4.3 (1.2)

 Triglycerides

82

1.3 (0.6)

1.3 (0.6)

1.6 (0.6)

 HDL cholesterol

81

1.4 (0.5)

1.4 (0.5)

1.5 (0.5)

 LDL cholesterol

80

2.0 (0.7)

2.0 (0.7)

1.9 (1)

 Non-HDL cholesterol

81

2.6 (0.8)

2.6 (0.8)

2.8 (0.8)

Estimated GFR (ml/min)

79

67.5 (11.6)

68.0 (11.3)

60.8 (13.7)

Glucose (mmol/L)

77

5.6 (1.6)

5.6 (1.6)

5.7 (2.0)

  1. Percentages are calculated from the number of patients with data for that particular variable
  2. + Minimisation variable - from June 2013 limited to age, ACE-R, systolic blood pressure and total cholesterol because of low recruitment ^ Protocol violation
  3. BP: blood pressure; bpm: beats per minute; HDL: high density lipoprotein; IS: ischaemic stroke; ICH: intracerebral haemorrhage; LDL: low density lipoprotein; MMSE: Mini-Mental State Examination; MoCA: Montreal Cognitive Assessment; NIHSS: National Institutes of Health Stroke Scale; OCSP: Oxfordshire Community Stroke Project; TICS-M: Telephone Interview for Cognitive Status-modified
  4. Memory problem: As reported by patient or informant in response to direct questioning, and information from hospital records
  5. MoCA: Estimated from ACE-R with addition of missing questions for attention (reading list of digits forwards and backwards, reading list of letters and tap with hand at each letter A) and abstraction (similarity between banana and orange, similarity between train and bicycle) and use of the ACE-R, not MoCA, picture of an animal. Non-HDL cholesterol = total cholesterol – HDL cholesterol
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