Study | Real-world data source | Key differences (real-world versus RCT patients) | Main author conclusionsb |
---|---|---|---|
Cardiology | |||
Badano et al., 2003 [15] | MC-PR | Older, more female, higher rates of concomitant diabetes, greater LVF clinical impairment | Different |
Björklund et al., 2004 [17] | MC-PR | Older, more female and more CV risk factors | Different |
Costantino et al., 2009a [21] | SC-PR | Older, more female, lower NYHA class | Different |
Dhruva et al., 2008 [22] | ID | Older, more female | Different |
Ezekowitz et al., 2012 [24] | MC-PR | Older, more female, more co-morbidities/prior cancer | Different |
Golomb et al., 2012 [27] | MC-PR | Increased self-rated physical activity with increasing age | Different |
Hutchinson-Jaffe et al., 2010 [29] | MC-PR | Older, more female, more co-morbidities, less guideline-recommended treatment/procedures | Different |
Melloni et al., 2010 [37] | MC-PR | More female | Different |
Steinberg et al., 2007 [62] | MC-PR | Older, more co-morbidities/CVD history | NE |
Uijen et al., 2007a [44] | MC-PR | Older, more female, higher CVD risk | Different |
Wagner et al., 2011 [65] | ID | Older, more chronic diseases | NE |
Mental health | |||
Kushner et al., 2009 [57] | MC-PR | Greater depression severity (some scales), lower preference for novel experiences | NE |
Rabinowitz et al., 2003a [59] | MC-PR | No major differences | Similar |
Riedel et al., 2005 [60] | SC-PR | Older, longer duration of illness, more internistic co-morbidities/hospitalizations | Similar |
Surman et al., 2010a [42] | SC-PR | More co-morbidities, anxiety/depression, alcohol/substance dependence | Different |
Zarin et al., 2005a [49] | MC-PR | Older, more female/Caucasian | Different |
Oncology | |||
Baquet et al., 2009 [52] | MC-PR | Fewer females (non-sex-specific tumor RCTs), fewer males (sex-specific tumor RCTs) | NE |
Elting et al., 2006 [23] | SC-PR | Older, more females/chronic co-morbidities, worse health/performance status | Different |
Fraser et al., 2011a [25] | MC-PR | Worse disease prognosis, more drug-related toxicity, lower drug dose intensity | Different |
Jennens et al., 2006 [30] | MC-PR | Older | Different |
Kalata et al., 2009 [31] | MC-PR | Older, more females, worse prognosis | Different |
Mengis et al., 2003a [38] | SC-PR | Older, worse performance status, more infections/AML-MDS subtypes | Different |
van der Linden et al., 2014 [45] | MC-PR | Older, more females, poor prognostic factors | Different |
Yennurajalingam et al., 2013 [48] | SC-PR | Older, more males, higher symptom intensity scores | Different |
Yessaian et al., 2005 [66] | MC-PR | No major differences | Similar |